Financiado en parte por General Mills, Cereal Partners Worldwide
Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
Roager HM, Vogt JK, Kristensen M, Hansen LBS, Ibrügger S, Mærkedahl RB, Bahl MI, Lind MV, Nielsen RL, Frøkiær H, Gøbel RJ, Landberg R, Ross AB, Brix S, Holck J, Meyer AS, Sparholt MH, Christensen AF, Carvalho V, Hartmann B, Holst JJ, Rumessen JJ, Linneberg A, Sicheritz-Pontén T, Dalgaard MD, Blennow A, Frandsen HL, Villas-Bôas S, Kristiansen K, Vestergaard H, Hansen T, Ekstrøm CT, Ritz C, Nielsen HB, Pedersen OB, Gupta R, Lauritzen L, Licht TR
Gut · 345 citas
Etiquetas de revisión
Vínculos de autores con la industriaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Biomarcadores de consumo
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- General Mills
- Gobierno
- Innovationsfonden
- Universidad u hospital
- Steno Diabetes Center Copenhagen
- Universidad u hospital
- University of Auckland
- Universidad u hospital
- Danmarks Tekniske Universitet
- Gobierno
- Region Hovedstaden
- Universidad u hospital
- Sino-Danish Center
- Empresa
- Cereal Partners Worldwide
- Universidad u hospital
- NNF Center for Basic Metabolic Research
- Gobierno
- Innovation Fund Denmark
- Universidad u hospital
- Steno Diabetes Center Copenhagen (SDCC)
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- Steno Diabetes Center Copenhagen (SDCC 3.F CMP)
Según 11 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-11-01 · Gut · vol. 68 · número 1 · págs. 83–93
- Editorial
- BMJ
- Citado
- 448 citas · más que el 99% de estudios similares · 11.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 61 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Gut microbiota and health · Food composition and properties · Celiac Disease Research and Management
- Palabras clave
- Microbiome, Whole grains, Insulin resistance, Internal medicine, Medicine, Systemic inflammation, Refined grains, Endocrinology, Food science, Insulin, Physiology, Animal science, Biology, Inflammation, Bioinformatics
- MeSH
- feces, humans, insulin resistance, inflammation, weight loss, blood glucose, lipids, interleukin-6, diet, cross-over studies, energy intake, adult, aged, middle aged, denmark, female, male, metabolomics, gastrointestinal microbiome, whole grains
38 autores
- Henrik Munch Roager🇩🇰Technical University of Denmark
- Josef Korbinian Vogt🇩🇰Technical University of Denmark
- Mette Kristensen🇩🇰University of Copenhagen
- Lea Benedicte Skov Hansen🇩🇰Technical University of Denmark
- Sabine Ibrügger🇩🇰University of Copenhagen
- Rasmus Baadsgaard Mærkedahl🇩🇰University of Copenhagen
- Martin Iain Bahl🇩🇰Technical University of Denmark
- Mads Vendelbo Lind🇩🇰🇸🇪University of Copenhagen; Chalmers University of Technology
- Rikke Linnemann Nielsen🇩🇰Technical University of Denmark
- Hanne Frøkiær🇩🇰University of Copenhagen
- Rikke J. Gøbel🇩🇰University of Copenhagen; Novo Nordisk Foundation
- Rikard Landberg🇸🇪Chalmers University of Technology
- Alastair B. Ross🇸🇪Chalmers University of Technology
- Susanne Brix🇩🇰Technical University of Denmark
- Jesper Holck🇩🇰Technical University of Denmark
- Anne S. Meyer🇩🇰Technical University of Denmark
- Morten H. Sparholt🇩🇰Bispebjerg Hospital
- Anders Fogh Christensen🇩🇰Bispebjerg Hospital
- Vera Carvalho🇩🇰Technical University of Denmark
- Bolette Hartmann🇩🇰University of Copenhagen; Novo Nordisk Foundation
- Jens Juul Holst🇩🇰University of Copenhagen; Novo Nordisk Foundation
- Jüri Johannes Rumessen🇩🇰Gentofte Hospital
- Allan R Linneberg🇩🇰University of Copenhagen; Rigshospitalet
- Thomas Sicheritz‐Pontén🇩🇰Technical University of Denmark
- Marlene Dalgaard🇩🇰Technical University of Denmark
- Andreas Blennow🇩🇰University of Copenhagen
- Henrik Lauritz Frandsen🇩🇰Technical University of Denmark
- Silas Granato Villas-Bôas🇳🇿University of Auckland
- Karsten Kristiansen🇩🇰University of Copenhagen
- Henrik Vestergaard🇩🇰University of Copenhagen; Steno Diabetes Centers; Novo Nordisk Foundation; Steno Diabetes Center Copenhagen
- Torben F. Hansen🇩🇰University of Copenhagen; Novo Nordisk Foundation
- Claus Thorn Ekstrøm🇩🇰University of Copenhagen
- Christian Ritz🇩🇰University of Copenhagen
- Henrik Bjørn Nielsen🇩🇰Clinical Microbiomics (Denmark); Technical University of Denmark
- Oluf Borbye Pedersen🇩🇰University of Copenhagen; Novo Nordisk Foundation
- Ramneek Gupta🇩🇰 · autor de correspondenciaTechnical University of Denmark
- Lotte Lauritzen🇩🇰University of Copenhagen
- Tine Rask Licht🇩🇰Technical University of Denmark
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To investigate whether a whole grain diet alters the gut microbiome and insulin sensitivity, as well as biomarkers of metabolic health and gut functionality.
Design
60 Danish adults at risk of developing metabolic syndrome were included in a randomised cross-over trial with two 8-week dietary intervention periods comprising whole grain diet and refined grain diet, separated by a washout period of ≥6 weeks. The response to the interventions on the gut microbiome composition and insulin sensitivity as well on measures of glucose and lipid metabolism, gut functionality, inflammatory markers, anthropometry and urine metabolomics were assessed.
Results
50 participants completed both periods with a whole grain intake of 179±50 g/day and 13±10 g/day in the whole grain and refined grain period, respectively. Compliance was confirmed by a difference in plasma alkylresorcinols (p<0.0001). Compared with refined grain, whole grain did not significantly alter glucose homeostasis and did not induce major changes in the faecal microbiome. Also, breath hydrogen levels, plasma short-chain fatty acids, intestinal integrity and intestinal transit time were not affected. The whole grain diet did, however, compared with the refined grain diet, decrease body weight (p<0.0001), serum inflammatory markers, interleukin (IL)-6 (p=0.009) and C-reactive protein (p=0.003). The reduction in body weight was consistent with a reduction in energy intake, and IL-6 reduction was associated with the amount of whole grain consumed, in particular with intake of rye.
Conclusion
Compared with refined grain diet, whole grain diet did not alter insulin sensitivity and gut microbiome but reduced body weight and systemic low-grade inflammation.
Trial registration number
NCT01731366; Results.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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