The effect of acute and 7-days dietary nitrate on mechanical efficiency, exercise performance and cardiac biomarkers in patients with chronic obstructive pulmonary disease
Beijers RJHCG, Huysmans SMD, van de Bool C, Kingma BRM, Verdijk LB, van Loon LJC, Meex SJR, Gosker HR, Schols AMWJ
Clinical nutrition (Edinburgh, Scotland) · 27 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Posiblemente financiado por la industria
- Organización sin fines de lucro
- European Society for Clinical Nutrition and Metabolism
- Empresa
- Nutricia Research and Lung Foundation Netherlands
Según 2 financiadores declarados.
Publicación
- Publicado
- 2017-10-31 · Clin Nutr · vol. 37 · número 6 · págs. 1852–1861
- Editorial
- Elsevier BV
- Citado
- 33 citas · más que el 79% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 61 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Cardiovascular and exercise physiology · Chronic Obstructive Pulmonary Disease (COPD) Research · Nitric Oxide and Endothelin Effects
- Palabras clave
- dietary nitrate, chronic obstructive pulmonary disease, mechanical efficiency, exercise performance, cardiac biomarkers, blood pressure, beetroot juice, cardiometabolic risk, exercise capacity
- MeSH
- heart, humans, pulmonary disease, chronic obstructive, nitrates, nitrites, body mass index, exercise, diet, cross-over studies, double-blind method, energy metabolism, oxygen consumption, blood pressure, aged, middle aged, female, male, obesity, abdominal, biomarkers
9 autores
- Rosanne J.H.C.G. Beijers🇳🇱 · autor de correspondenciaMaastricht University Medical Centre; Maastricht University
- Stephanie Huysmans🇳🇱Maastricht University Medical Centre
- Coby van de Bool🇳🇱Maastricht University Medical Centre
- Boris Kingma🇳🇱Netherlands Organisation for Applied Scientific Research; Maastricht University Medical Centre; Maastricht University
- Lex B. Verdijk🇳🇱Maastricht University Medical Centre; Maastricht University
- Luc J. C. van Loon🇳🇱Maastricht University Medical Centre; Maastricht University
- Steven J.R. Meex🇳🇱Maastricht University Medical Centre
- Harry R. Gosker🇳🇱Maastricht University Medical Centre
- Annemie M.W.J. Schols🇳🇱Maastricht University Medical Centre
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Many COPD patients have a reduced exercise capacity and mechanical efficiency and are at increased cardiometabolic risk. This study aimed to assess acute and 7-days effects of dietary nitrate on mechanical efficiency, exercise performance and cardiac biomarkers in patients with COPD.
Methods
This double-blind, randomized cross-over placebo controlled trial included 20 mild-to-moderate COPD patients (66.6 ± 7.5 years) with moderate exercise impairments and decreased mechanical efficiency, normal BMI (26 ± 3 kg/m2) but high prevalence of abdominal obesity (83.3%). Subjects were randomly allocated to the treatment order of 7 days sodium nitrate ingestion (∼8 mmol/day) and 7 days placebo (NaCl solution) or vice versa, separated by a washout period. Before (Day-1) and after (Day-7) both intervention periods resting metabolic rate and the metabolic response during submaximal cycle ergometry, cycling endurance time, plasma nitrate and nitrite levels, cardiac plasma biomarkers (e.g. cardiac troponin T, Nt-proBNP and creatinine kinase) and blood pressure were measured. Subsequently, gross, net and delta mechanical efficiency were calculated.
Results
Plasma nitrate and nitrite concentrations increased at Day-1 and Day-7 after sodium nitrate but not after placebo ingestion. Systolic and diastolic blood pressure did not change following nitrate ingestion. Furthermore, no differences were observed in gross, net, and delta mechanical efficiency during submaximal exercise, cycling endurance time and cardiac biomarkers between nitrate and placebo on Day-1 and Day-7. Meta-analysis of all available studies in COPD also showed no beneficial effect of beetroot juice on systolic and diastolic blood pressure.
Conclusion
Acute as well as 7-days sodium nitrate supplementation does not modulate mechanical efficiency, blood pressure or cardiac biomarkers in mild-to-moderate COPD patients.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.