Financiado en parte por Novo Nordisk, Novo Nordisk Fonden
Effects of Vitamin D Supplementation on Semen Quality, Reproductive Hormones, and Live Birth Rate: A Randomized Clinical Trial
Blomberg Jensen M, Lawaetz JG, Petersen JH, Juul A, Jørgensen N
The Journal of clinical endocrinology and metabolism · 98 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiado por la industria
- Organización sin fines de lucro
- Hørslev-Fonden
- Empresa
- Novo Nordisk
- Empresa
- Novo Nordisk Fonden
- Subvenciones
- Novo Nordisk Fonden (NNF17OC0026096)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2017-11-03 · J Clin Endocrinol Metab · vol. 103 · número 3 · págs. 870–881
- Editorial
- Oxford University Press
- Citado
- 128 citas · más que el 99% de estudios similares · 10.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Sperm and Testicular Function · Vitamin D Research Studies · Male Reproductive Health Studies
- Palabras clave
- vitamin D supplementation, vitamin D3, calcium supplementation, male infertility, semen quality, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D3, inhibin B, live birth rate, oligozoospermia, vitamin D deficiency, male reproductive hormones
- MeSH
- humans, infertility, male, oligospermia, vitamin d deficiency, calcium, cholecalciferol, vitamin d, sperm count, pregnancy outcome, drug therapy, combination, pregnancy rate, double-blind method, sperm motility, pregnancy, dietary supplements, adult, middle aged, female, male, semen analysis
5 autores
- Martin Blomberg Jensen🇩🇰🇺🇸 · autor de correspondenciaUniversity of Copenhagen; Harvard University; Rigshospitalet
- Jacob Gerner Lawaetz🇩🇰University of Copenhagen; Rigshospitalet
- Jørgen Holm Petersen🇩🇰University of Copenhagen; Rigshospitalet
- Anders Juul🇩🇰University of Copenhagen; Rigshospitalet
- Niels Jørgensen🇩🇰University of Copenhagen; Rigshospitalet
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Results of animal models and cross-sectional cohort studies have suggested a beneficial role for vitamin D in male reproduction.
Objective
Determine the effect of vitamin D and calcium supplementation on semen quality in infertile men with serum 25-hydroxyvitamin-D (25OHD) levels ≤50 nmol/L.
Design
A single-center, triple-blinded, randomized clinical trial.
Participants
A total of 1427 infertile men were screened to include 330; 1002 men did not meet inclusion criteria and 95 did not wish to participate.
Intervention
The active group received cholecalciferol 300,000 IU initially, then 1400 IU cholecalciferol and 500 mg of calcium daily for 150 days; the other group received placebo.
Results
Serum concentrations of 25OHD and 1,25-dihydroxyvitamin D3 were significantly higher in men in the treatment group compared with the placebo group. Vitamin D supplementation was not associated with changes in semen parameters, although spontaneous pregnancies tended to be higher in couples in which the man was in the treatment group [7.3% vs 2.4%, Δ5.0% (-0.6%; 10.5%)]. Vitamin D treatment in a subgroup of oligozoospermic men increased the chance for a live birth compared with placebo [35.6% vs 18.3%, Δ17.3% (1.6%; 32.9%)]. Moreover, serum inhibin B levels were higher in men deficient in vitamin D who were randomly assigned to receive high-dose vitamin D [193 pg/mL vs 143 pg/mL, Δ49 pg/mL (8; 91 pg/mL)]; however, the increase in sperm concentration was not significantly higher than in the placebo group (P = 0.07).
Conclusion
High-dose vitamin D supplementation did not improve semen quality in vitamin D-insufficient infertile men. The positive impact of vitamin D supplementation on live birth rate and serum inhibin B in oligozoospermic and vitamin D-deficient men may be of clinical importance and warrant verification by others.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.