High-density lipoprotein cholesterol efflux capacity is inversely associated with cardiovascular risk: a systematic review and meta-analysis
Qiu C, Zhao X, Zhou Q, Zhang Z
Lipids in health and disease · 61 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- Central South University
- Gobierno
- Natural Science Foundation of Hainan Province
- Universidad u hospital
- Xiangya Hospital, Central South University
- Gobierno
- the Natural Science Foundation of Hunan Province, China
- Gobierno
- The National Science Foundation of China (NSFC) Project
- Universidad u hospital
- the New Xiangya Talent Projects of the Third xiangya hospital of Central South University
- Subvenciones
- Natural Science Foundation of Hainan Province (2017JJ3250); Xiangya Hospital, Central South University (JY201626)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-11-10 · Lipids Health Dis · vol. 16 · número 1 · pág. 212
- Editorial
- BioMed Central
- Citado
- 83 citas · más que el 83% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Cholesterol and Lipid Metabolism · Paraoxonase enzyme and polymorphisms
- Palabras clave
- HDL cholesterol, cholesterol efflux capacity, cardiovascular risk, cardiovascular events, all-cause mortality, cardiovascular risk prediction, HDL metabolism, macrophages
- MeSH
- humans, cardiovascular diseases, lipoproteins, hdl, risk factors, adult, aged, middle aged, female, male
4 autores
- Chengfeng Qiu🇨🇳Central South University; Third Xiangya Hospital
- Xiang Zhao
- Quan Zhou🇨🇳The First People's Hospital of Changde
- Zhen Zhang🇨🇳 · autor de correspondenciaCentral South University; Third Xiangya Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
A low plasma level of high-density lipoprotein (HDL) cholesterol (HDL-C) is associated with cardiovascular risk. A key cardioprotective property of HDL is cholesterol efflux capacity (CEC), the ability of HDL to accept cholesterol from macrophages. In this study, we aimed to identify the predictive value of CEC for cardiovascular risk.
Methods
The relative risks (RRs) and 95% confidence intervals (CIs) were pooled to analyze the association between CEC and the incidence of cardiovascular events and all-cause mortality. The odds ratios (ORs) and 95% CIs were pooled to estimate the association of CEC and the prevalence of cardiovascular events.
Results
A total of 15 studies were included. Results showed that the highest CEC was significantly associated with a reduced risk of cardiovascular events incidents compared to the lowest CEC (RR, 0.56; 95% CI, 0.37 to 0.85; I 2, 89%); the pooled RR of cardiovascular risk for per unit SD increase was 0.87 (95% CI, 0.73 to 1.04; I 2, 67%). Dose-response curve indicated that cardiovascular risk decreased by 39% (RR, 0.61; 95% CI, 0.51 to 0.74) for per unit CEC increase. Similarly, an inverse association was observed between CEC and the prevalence of cardiovascular events (highest vs. lowest, OR, 0.30; 95% CI, 0.17 to 0.5; I 2 = 63%; per unit SD increase, OR, 0.94; 95% CI, 0.90 to 0.98; I 2 = 71%). However, based on the current data, CEC was not significantly associated with all-cause mortality.
Conclusions
Findings from this meta-analysis suggest that HDL-mediated CEC is inversely associated with cardiovascular risk, which appears to be independent of HDL concentration. The growing understanding of CEC and its role in cardiovascular risk decrease may improve the accuracy of cardiovascular risk prediction and also open important avenues to develop novel therapeutic targeting HDL metabolism.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.