Acute and chronic cold exposure differentially affects the browning of porcine white adipose tissue
Gao Y, Qimuge NR, Qin J, Cai R, Li X, Chu GY, Pang WJ, Yang GS
Animal : an international journal of animal bioscience · 27 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- National Science and Technology Major Project
- Subvenciones
- National Natural Science Foundation of China (31572366); National Science and Technology Major Project (2016ZX08006-003); National Natural Science Foundation of China (2016ZX08006-003); National Natural Science Foundation of China (2015CB943102)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2017-11-16 · Animal · vol. 12 · número 7 · págs. 1435–1441
- Editorial
- Elsevier BV
- Citado
- 39 citas · más que el 82% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 30 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Adipose Tissue and Metabolism · Exercise and Physiological Responses · Adipokines, Inflammation, and Metabolic Diseases
- Palabras clave
- Browning, Thermogenesis, Thermogenin, White adipose tissue, Brown adipose tissue, Mitochondrial biogenesis, Adipose tissue, PRDM16, Endocrinology, Uncoupling protein, Internal medicine, Biology, Chemistry, Biochemistry, Medicine, Mitochondrion
- MeSH
- animals, swine, humans, thermogenesis, subcutaneous fat, adipose tissue, white, cold temperature, uncoupling protein 1
8 autores
- Yanbin Gao🇨🇳North West Agriculture and Forestry University; Northwest A&F University
- Naren Qimuge🇨🇳North West Agriculture and Forestry University; Northwest A&F University
- Jing Qin🇨🇳North West Agriculture and Forestry University; Northwest A&F University
- Rui Cai🇨🇳North West Agriculture and Forestry University; Northwest A&F University
- X. Li🇨🇳North West Agriculture and Forestry University; Northwest A&F University
- Guiyan Chu🇨🇳North West Agriculture and Forestry University; Northwest A&F University
- Weijun Pang🇨🇳 · autor de correspondenciaNorth West Agriculture and Forestry University; Northwest A&F University
- Gongshe Yang🇨🇳 · autor de correspondenciaNorth West Agriculture and Forestry University; Northwest A&F University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Piglets are characteristically cold intolerant and thus susceptible to high mortality. However, browning of white adipose tissue (WAT) can induce non-shivering thermogenesis as a potential strategy to facilitate the animal's response to cold. Whether cold exposure can induce browning of subcutaneous WAT (sWAT) in piglets in a similar manner as it can in humans remains largely unknown. In this study, piglets were exposed to acute cold (4°C, 10 h) or chronic cold exposure (8°C, 15 days), and the genes and proteins of uncoupling protein 1 (UCP1)-dependent and independent thermogenesis, mitochondrial biogenesis, lipogenic and lipolytic processes were analysed. Interestingly, acute cold exposure induced browning of porcine sWAT, smaller adipocytes and the upregulated expression of UCP1, PGC1α, PGC1β, C/EBPβ, Cidea, UCP3, CKMT1 and PM20D1. Conversely, chronic cold exposure impaired the browning process, reduced mitochondrial numbers and the expression of browning markers, including UCP1, PGC1α and PRDM16. The present study demonstrated that acute cold exposure (but not chronic cold exposure) induces porcine sWAT browning. Thus, browning of porcine sWAT could be a novel strategy to balance the body temperature of piglets, and thus could be protective against cold exposure.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.