High plasma 25-hydroxyvitamin D and high risk of nonmelanoma skin cancer: a Mendelian randomization study of 97 849 individuals
Winsløw UC, Nordestgaard BG, Afzal S
The British journal of dermatology · 25 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Hjerteforeningen
- Universidad u hospital
- Gentofte Hospital
- Universidad u hospital
- Herlev and Gentofte Hospital
Según 3 financiadores declarados.
Publicación
- Publicado
- 2017-11-16 · Br J Dermatol · vol. 178 · número 6 · págs. 1388–1395
- Editorial
- Oxford University Press
- Citado
- 50 citas · más que el 78% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 53 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Thyroid Cancer Diagnosis and Treatment · Skin Protection and Aging
- Palabras clave
- Vitamin D and neurology, Skin cancer, Hazard ratio, Internal medicine, Confidence interval, Mendelian randomization, Medicine, Odds ratio, Population, Endocrinology, Cancer, Biology, Genetics, Genotype, Genetic variants, Gene
- MeSH
- humans, skin neoplasms, vitamin d, risk factors, cohort studies, sunlight, environmental exposure, genotype, adult, aged, aged, 80 and over, middle aged, denmark, female, male, young adult, mendelian randomization analysis
3 autores
- Ulrik Winsløw🇩🇰University of Copenhagen; Copenhagen University Hospital; Gentofte Hospital
- Børge Grønne Nordestgaard🇩🇰University of Copenhagen; Copenhagen University Hospital; Gentofte Hospital
- Shoaib Afzal🇩🇰 · autor de correspondenciaUniversity of Copenhagen; Copenhagen University Hospital; Gentofte Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
High plasma 25-hydroxyvitamin D [25(OH)D] concentration has been associated observationally with a high risk of nonmelanoma skin cancer (NMSC), whereas many studies suggest that vitamin D could have a protective effect against cancer. The true association between vitamin D and risk of skin cancer remains unclear.
Objectives
To test the hypothesis that genetically high plasma 25(OH)D protects against NMSC.
Methods
We included 103 084 individuals from the Danish general population, of whom 35 298 had plasma 25(OH)D measured and 97 849 were genotyped for four genetic variants near DHCR7 and CYP2R1 associated with 25(OH)D concentrations. We tested the association between plasma 25(OH)D levels and NMSC observationally and between genetically determined 25(OH)D levels and NMSC, using an instrumental variable approach.
Results
Multivariate-adjusted hazard ratios of NMSC were 3·27 [95% confidence interval (CI) 2·22-4·84] for plasma 25(OH)D ≥ 50 nmol L-1 vs. -1 . Genetic variants around DHCR7 and CYP2R1 were associated with up to 8·2 nmol L-1 higher 25(OH)D concentrations (F = 314). The odds ratio (OR) for a genetically determined 20 nmol L-1 higher plasma 25(OH)D was 1·11 (95% CI 0·91-1·35) for NMSC, with a corresponding observational multivariable adjusted OR of 1·13 (95% CI 1·10-1·17).
Conclusions
Genetically determined high 25(OH)D levels did not appear to protect against NMSC, whereas high plasma 25(OH)D concentrations were associated with an observational high risk of NMSC. Thus, the observational association likely reflects confounding by sun exposure rather than causality.
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