Financiado en parte por Almond Board of California
Effects of Dark Chocolate and Almonds on Cardiovascular Risk Factors in Overweight and Obese Individuals: A Randomized Controlled-Feeding Trial
Lee Y, Berryman CE, West SG, Chen CO, Blumberg JB, Lapsley KG, Preston AG, Fleming JA, Kris-Etherton PM
Journal of the American Heart Association · 43 citas
Etiquetas de revisión
Vínculos de autores con la industriaAlimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- University of Pennsylvania
- Grupo de la industria
- Almond Board of California
- Universidad u hospital
- Pennsylvania State University
- Gobierno
- National Institutes of Health
- Gobierno
- National Center for Advancing Translational Sciences
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-11-30 · J Am Heart Assoc · vol. 6 · número 12
- Editorial
- Wiley
- Citado
- 81 citas · más que el 96% de estudios similares · 5.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Nuts composition and effects · Antioxidant Activity and Oxidative Stress · Nutritional Studies and Diet
- Palabras clave
- Dark chocolate, Medicine, Overweight, Crossover study, Randomized controlled trial, Cholesterol, Lipoprotein, Internal medicine, Obesity, Food science, Biology, Placebo
- MeSH
- humans, cardiovascular diseases, obesity, body mass index, prognosis, incidence, risk assessment, risk factors, cross-over studies, adult, aged, middle aged, pennsylvania, female, male, overweight, cholesterol, hdl, prunus dulcis, chocolate
9 autores
- Yujin Lee🇺🇸Pennsylvania State University
- Claire E. Berryman🇺🇸Pennsylvania State University
- Sheila G. West🇺🇸Pennsylvania State University
- C.‐Y. Oliver Chen🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Jeffrey B. Blumberg🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Karen G. Lapsley🇺🇸Almond Board of California
- Amy G. Preston🇺🇸Hershey (United States)
- Jennifer A Fleming🇺🇸Pennsylvania State University
- Penny M. Kris‐Etherton🇺🇸Pennsylvania State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Consumption of almonds or dark chocolate and cocoa has favorable effects on markers of coronary heart disease; however, the combined effects have not been evaluated in a well-controlled feeding study. The aim of this study was to examine the individual and combined effects of consumption of dark chocolate and cocoa and almonds on markers of coronary heart disease risk.
Methods and results
A randomized controlled, 4-period, crossover, feeding trial was conducted in overweight and obese individuals aged 30 to 70 years. Forty-eight participants were randomized, and 31 participants completed the entire study. Each diet period was 4 weeks long, followed by a 2-week compliance break. Participants consumed each of 4 isocaloric, weight maintenance diets: (1) no treatment foods (average American diet), (2) 42.5 g/d of almonds (almond diet [ALD]), (3) 18 g/d of cocoa powder and 43 g/d of dark chocolate (chocolate diet [CHOC]), or (4) all 3 foods (CHOC+ALD). Compared with the average American diet, total cholesterol, non-high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol after the ALD were lower by 4%, 5%, and 7%, respectively (PP=0.04), whereas the CHOC+ALD had a greater decrease in small dense low-density lipoprotein particles (-12.0±2.8 versus -5.3±2.8 mg/dL; P=0.04). There were no significant differences between diets for measures of vascular health and oxidative stress.
Conclusions
Our results demonstrate that consumption of almonds alone or combined with dark chocolate under controlled-feeding conditions improves lipid profiles. Incorporating almonds, dark chocolate, and cocoa into a typical American diet without exceeding energy needs may reduce the risk of coronary heart disease.
Clinical trial registration
URL: https://www.clinicaltrials.gov. Unique identifier: NCT01882881.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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