A Mediterranean-style dietary intervention supplemented with fish oil improves diet quality and mental health in people with depression: A randomized controlled trial (HELFIMED)
Parletta N, Zarnowiecki D, Cho J, Wilson A, Bogomolova S, Villani A, Itsiopoulos C, Niyonsenga T, Blunden S, Meyer B, Segal L, Baune BT, O'Dea K
Nutritional neuroscience · 401 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of South Australia
- Gobierno
- Medical Research Council
- Gobierno
- Australian Research Council
- Gobierno
- National Health and Medical Research Council
- Subvenciones
- Australian Research Council (DE130101577); National Health and Medical Research Council (631947); National Health and Medical Research Council (320860)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2017-12-07 · Nutr Neurosci · vol. 22 · número 7 · págs. 474–487
- Editorial
- Taylor & Francis
- Citado
- 631 citas · más que el 100% de estudios similares · 31.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 59 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Nutritional Studies and Diet · Fatty Acid Research and Health · Diet and metabolism studies
- Palabras clave
- Randomized controlled trial, Mental health, Mediterranean diet, Depression (economics), Intervention (counseling), Fish oil, Fish <Actinopterygii>, Environmental health, Medicine, Psychiatry, Psychology, Biology, Internal medicine, Fishery
- MeSH
- humans, fatty acids, omega-3, fatty acids, omega-6, fish oils, treatment outcome, depression, mental health, diet, mediterranean, quality of life, dietary supplements, adolescent, adult, aged, middle aged, female, male, young adult
13 autores
- Natalie Parletta🇦🇺 · autor de correspondenciaUniversity of South Australia
- Dorota M. Zarnowiecki🇦🇺University of South Australia
- Ji‐Hyun Cho🇦🇺University of South Australia
- Amy L. Wilson🇦🇺University of South Australia
- Svetlana Bogomolova🇦🇺University of South Australia
- Anthony M. Villani🇦🇺University of the Sunshine Coast
- Catherine Itsiopoulos🇦🇺La Trobe University
- Theo Niyonsenga🇦🇺University of South Australia; University of Canberra; ACT Government
- Sarah Lee Blunden🇦🇺Central Queensland University
- Barbara J. Meyer🇦🇺University of Wollongong
- Leonie Segal🇦🇺University of South Australia
- Bernhard Theodor Baune🇦🇺Royal Adelaide Hospital; The University of Adelaide
- Kerin O’Dea🇦🇺University of South Australia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
We investigated whether a Mediterranean-style diet (MedDiet) supplemented with fish oil can improve mental health in adults suffering depression.
Methods
Adults with self-reported depression were randomized to receive fortnightly food hampers and MedDiet cooking workshops for 3 months and fish oil supplements for 6 months, or attend social groups fortnightly for 3 months. Assessments at baseline, 3 and 6 months included mental health, quality of life (QoL) and dietary questionnaires, and blood samples for erythrocyte fatty acid analysis.
Results
n = 152 eligible adults aged 18-65 were recruited (n = 95 completed 3-month and n = 85 completed 6-month assessments). At 3 months, the MedDiet group had a higher MedDiet score (t = 3.95, P < 0.01), consumed more vegetables (t = 3.95, P < 0.01), fruit (t = 2.10, P = 0.04), nuts (t = 2.29, P = 0.02), legumes (t = 2.41, P = 0.02) wholegrains (t = 2.63, P = 0.01), and vegetable diversity (t = 3.27, P < 0.01); less unhealthy snacks (t = -2.10, P = 0.04) and red meat/chicken (t = -2.13, P = 0.04). The MedDiet group had greater reduction in depression (t = -2.24, P = 0.03) and improved mental health QoL scores (t = 2.10, P = 0.04) at 3 months. Improved diet and mental health were sustained at 6 months. Reduced depression was correlated with an increased MedDiet score (r = -0.298, P = 0.01), nuts (r = -0.264, P = 0.01), and vegetable diversity (r = -0.303, P = 0.01). Other mental health improvements had similar correlations, most notably for increased vegetable diversity and legumes. There were some correlations between increased omega-3, decreased omega-6 and improved mental health.
Discussion
This is one of the first randomized controlled trials to show that healthy dietary changes are achievable and, supplemented with fish oil, can improve mental health in people with depression.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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