Vitamin D and gestational diabetes mellitus: a systematic review based on data free of Hawthorne effect
Zhang Y, Gong Y, Xue H, Xiong J, Cheng G
BJOG : an international journal of obstetrics and gynaecology · 90 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- Sichuan University
- Subvenciones
- National Natural Science Foundation of China (81472976)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2017-12-16 · BJOG · vol. 125 · número 7 · págs. 784–793
- Editorial
- Wiley
- Citado
- 124 citas · más que el 94% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Gestational Diabetes Research and Management · Vitamin D Research Studies · Birth, Development, and Health
- Palabras clave
- vitamin D, gestational diabetes mellitus, vitamin D deficiency, insulin resistance, fasting insulin, fasting blood glucose, C-reactive protein, glutathione, serum lipids, Hawthorne effect
- MeSH
- humans, diabetes, gestational, insulin resistance, vitamin d deficiency, insulin, blood glucose, vitamin d, fasting, risk factors, pregnancy, pregnancy trimesters, dietary supplements, female, randomized controlled trials as topic, observational studies as topic
5 autores
- Yanbo Zhang🇨🇳Sichuan University; Huazhong University of Science and Technology
- Yunhui Gong🇨🇳Sichuan University
- Hongmei Xue🇨🇳Sichuan University
- Jingyuan Xiong🇨🇳 · autor de correspondenciaSichuan University
- Guo Cheng🇨🇳 · autor de correspondenciaSichuan University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Gestational diabetes mellitus (GDM) is an increasingly prevalent disorder, associated with low blood vitamin D level.
Objectives
To evaluate the relationship between vitamin D and GDM.
Search strategy
EMBASE, MEDLINE, Cochrane Library and China Biology Medicine disc were searched up to May 2017. The references of previous studies were screened.
Selection criteria
Observational studies on the relationship between vitamin D and GDM free from Hawthorne effect and randomised controlled trials of vitamin D supplementation during pregnancy for preventing or treating GDM were included.
Data collection and analysis
Data and information of included articles were extracted by duplicate using piloted tables. Newcastle-Ottawa Scale and Cochrane Handbook were used for quality assessment. Random-effects models were used for meta-analyses. Heterogeneity tests, sensitivity analysis and analysis of publication bias were conducted.
Main results
Eighty-seven observational studies and 25 randomised controlled trials involving 55 859 and 2445 women, respectively, were included. Low blood vitamin D level during pregnancy was associated with a higher risk of GDM (OR 1.850, 95% CI 1.471-2.328). Blood vitamin D level for women with GDM were lower than in the control women. Blood vitamin D level was associated with fasting plasma glucose (FPG) and homeostasis model of assessment for insulin resistance index (HOMA-IR) (r = -0.100 and r = -0.351), whereas the correlation between blood vitamin D level and fasting insulin (FINS) might be concealed by publication bias. Vitamin D intervention during pregnancy could change the blood levels of vitamin D, FINS, FPG, HOMA-IR, glutathione, C-reactive protein and lipid.
Conclusions
Low blood vitamin D level could increase the risk of GDM, and vitamin D supplementation during pregnancy could ameliorate the condition of GDM.
Tweetable abstract
Low blood vitamin D increases gestational diabetes mellitus (GDM) risk. Vitamin D supplementation ameliorates GDM condition.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.