Financiado en parte por Nutrabolt
Hematological and Hemodynamic Responses to Acute and Short-Term Creatine Nitrate Supplementation
Dalton RL, Sowinski RJ, Grubic TJ, Collins PB, Coletta AM, Reyes AG, Sanchez B, Koozehchian M, Jung YP, Rasmussen C, Greenwood M, Murano PS, Earnest CP, Kreider RB
Nutrients · 18 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Nutrabolt
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-12-15 · Nutrients · vol. 9 · número 12 · pág. 1359
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 22 citas · más que el 62% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 75 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Sports Performance and Training · Biochemical effects in animals
- Palabras clave
- creatine supplementation, acute supplementation, short-term supplementation, hemodynamic response, blood markers, postural challenge, strength performance, bench press, leg press, cycling time trial, recovery performance, post-exercise recovery, adverse effects, dose comparison, sex differences, men and women
- MeSH
- muscle, skeletal, animals, humans, nitrates, creatine, anthropometry, treatment outcome, cross-over studies, double-blind method, body composition, physical endurance, dose-response relationship, drug, bicycling, dietary supplements, adolescent, adult, female, male, muscle strength, hemodynamics, athletic performance, young adult, performance-enhancing substances, surveys and questionnaires
14 autores
- R Dalton🇺🇸Texas A&M University
- Ryan J. Sowinski🇺🇸Texas A&M University
- Tyler Grubic🇺🇸Texas A&M University
- Patrick Collins🇺🇸Texas A&M University
- Adriana M. Coletta🇺🇸Texas A&M University
- A. Reyes🇺🇸Texas A&M University
- B Sanchez🇺🇸Texas A&M University
- M Koozehchian🇺🇸Texas A&M University
- Yanghoon Peter Jung🇺🇸Texas A&M University
- Christopher J. Rasmussen🇺🇸Texas A&M University
- Mike Greenwood🇺🇸Texas A&M University
- Peter S. Murano🇺🇸Texas A&M University
- Conrad P. Earnest🇺🇸Texas A&M University
- Richard B. Kreider🇺🇸 · autor de correspondenciaTexas A&M University
Resumen
El texto original del estudio, en el idioma en que se publicó.
In a double-blind, crossover, randomized and placebo-controlled trial; 28 men and women ingested a placebo (PLA), 3 g of creatine nitrate (CNL), and 6 g of creatine nitrate (CNH) for 6 days. Participants repeated the experiment with the alternate supplements after a 7-day washout. Hemodynamic responses to a postural challenge, fasting blood samples, and bench press, leg press, and cycling time trial performance and recovery were assessed. Data were analyzed by univariate, multivariate, and repeated measures general linear models (GLM). No significant differences were found among treatments for hemodynamic responses, clinical blood markers or self-reported side effects. After 5 days of supplementation, one repetition maximum (1RM) bench press improved significantly for CNH (mean change, 95% CI; 6.1 [3.5, 8.7] kg) but not PLA (0.7 [-1.6, 3.0] kg or CNL (2.0 [-0.9, 4.9] kg, CNH, p = 0.01). CNH participants also tended to experience an attenuated loss in 1RM strength during the recovery performance tests following supplementation on day 5 (PLA: -9.3 [-13.5, -5.0], CNL: -9.3 [-13.5, -5.1], CNH: -3.9 [-6.6, -1.2] kg, p = 0.07). After 5 days, pre-supplementation 1RM leg press values increased significantly, only with CNH (24.7 [8.8, 40.6] kg, but not PLA (13.9 [-15.7, 43.5] or CNL (14.6 [-0.5, 29.7]). Further, post-supplementation 1RM leg press recovery did not decrease significantly for CNH (-13.3 [-31.9, 5.3], but did for PLA (-30.5 [-53.4, -7.7] and CNL (-29.0 [-49.5, -8.4]). CNL treatment promoted an increase in bench press repetitions at 70% of 1RM during recovery on day 5 (PLA: 0.4 [-0.8, 1.6], CNL: 0.9 [0.35, 1.5], CNH: 0.5 [-0.2, 0.3], p = 0.56), greater leg press endurance prior to supplementation on day 5 (PLA: -0.2 [-1.6, 1.2], CNL: 0.9 [0.2, 1.6], CNH: 0.2 [-0.5, 0.9], p = 0.25) and greater leg press endurance during recovery on day 5 (PLA: -0.03 [-1.2, 1.1], CNL: 1.1 [0.3, 1.9], CNH: 0.4 [-0.4, 1.2], p = 0.23). Cycling time trial performance (4 km) was not affected. Results indicate that creatine nitrate supplementation, up to a 6 g dose, for 6 days, appears to be safe and provide some ergogenic benefit.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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