Magnesium supplementation affects gene expression related to insulin and lipid in patients with gestational diabetes
Jamilian M, Samimi M, Faraneh AE, Aghadavod E, Shahrzad HD, Chamani M, Mafi A, Asemi Z
Magnesium research · 22 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2017-07-01 · Magnes Res · vol. 30 · número 3 · págs. 71–79
- Editorial
- John Libbey Eurotext
- Citado
- 33 citas · más que el 84% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Metabolism, Diabetes, and Cancer
- Palabras clave
- Gestational diabetes, Endocrinology, Internal medicine, Placebo, Insulin, Lipid metabolism, Medicine, Lipid profile, Peripheral blood mononuclear cell, Diabetes mellitus, Gestation, Biology, Pregnancy, Biochemistry
- MeSH
- humans, diabetes, gestational, magnesium, insulin, double-blind method, pregnancy, dietary supplements, adolescent, adult, female, lipid metabolism, young adult
8 autores
- Mehri Jamilian🇮🇷Arak University of Medical Sciences
- Mansooreh Samimi🇮🇷Kashan University of Medical Sciences
- Afshar Ebrahimi Faraneh🇮🇷Kashan University of Medical Sciences
- Esmat Aghadavod🇮🇷Kashan University of Medical Sciences
- Hashemi Dizaji Shahrzad🇮🇷Iran University of Medical Sciences
- Maryam Chamani🇮🇷Iran University of Medical Sciences
- Alireza Mafi🇮🇷Kashan University of Medical Sciences
- Zatollah Asemi🇮🇷Kashan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Magnesium is known to exert several beneficial effects, including antiglycemic and antilipidemic properties. The aim of this study was to evaluate the effects of magnesium supplementation on gene expression related to insulin and lipid metabolism in women with gestational diabetes (GDM) who were not on oral hypoglycemic agents. This randomized double-blind, placebo-controlled trial was conducted among 40 patients diagnosed with GDM, aged 18-40 years. Participants were randomly allocated into two groups to take either 250 mg/day of magnesium supplements in the form of magnesium oxide (n = 20) or placebo (n = 20) for 6 weeks. Gene expression related to insulin and lipid metabolism was assessed in peripheral blood mononuclear cells (PBMCs) of women with GDM using RT-PCR method. Compared with the placebo, magnesium supplementation to women with GDM resulted in a significant decrease in levels of fasting plasma glucose (FPG) (-9.7 ± 5.6 vs. -0.1 ± 8.5 mg/dL, P<0.001). Quantitative results of RT-PCR demonstrated that compared with the placebo, magnesium supplementation upregulated gene expression of peroxisome proliferator-activated receptor gamma (PPAR-γ) (P = 0.003) and glucose transporter 1 (GLUT-1) (P = 0.004) and downregulated gene expression of oxidized low-density lipoprotein receptor (LDLR) (P = 0.001) in PBMCs of women with GDM. In addition, a trend toward a greater decrease in gene expression of lipoprotein (a) [LP(a)] was observed in the patients belonging to magnesium group compared to placebo group (P = 0.08). Overall, magnesium supplementation for 6 weeks in women with GDM significantly improved FPG levels, and gene expression of PPAR-γ, GLUT-1, and LDLR.
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