Effects of alternate-day fasting or daily calorie restriction on body composition, fat distribution, and circulating adipokines: Secondary analysis of a randomized controlled trial
Trepanowski JF, Kroeger CM, Barnosky A, Klempel M, Bhutani S, Hoddy KK, Rood J, Ravussin E, Varady KA
Clinical nutrition (Edinburgh, Scotland) · 113 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Universidad u hospital
- University of Illinois at Chicago
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (F32DK107157); National Heart, Lung, and Blood Institute (#T32 HL007034); National Heart, Lung, and Blood Institute (R01 HL106228); National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK-072476); National Institutes of Health (R01HL106228); National Institutes of Health (T32HL007034); National Institutes of Health (F32DK107157)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2017-12-05 · Clin Nutr · vol. 37 · número 6 · págs. 1871–1878
- Editorial
- Elsevier BV
- Citado
- 148 citas · más que el 96% de estudios similares · 4.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Dietary Effects on Health · Adipokines, Inflammation, and Metabolic Diseases · Regulation of Appetite and Obesity
- Palabras clave
- alternate-day fasting, body composition, body fat distribution, fat-free mass, leptin, adipokines, adiponectin, resistin, interleukin-6, TNF-α, obesity, overweight, caloric restriction
- MeSH
- humans, obesity, body weight, weight loss, leptin, treatment outcome, exercise, caloric restriction, diet, reducing, fasting, body composition, adult, middle aged, female, male, overweight, adipokines
9 autores
- John F. Trepanowski🇺🇸 · autor de correspondenciaUniversity of Illinois Chicago; Stanford University
- Cynthia M. Kroeger🇺🇸University of Illinois Chicago; Indiana University Bloomington; Indiana University
- Adrienne Barnosky🇺🇸University of Illinois Chicago
- Monica C Klempel🇺🇸University of Illinois Chicago
- Surabhi Bhutani🇺🇸University of Illinois Chicago
- Kristin K. Hoddy🇺🇸University of Illinois Chicago
- Jennifer Carlton Rood🇺🇸Pennington Biomedical Research Center
- Éric Ravussin🇺🇸Pennington Biomedical Research Center
- Krista A Varady🇺🇸University of Illinois Chicago
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Indirect comparisons suggest that alternate-day fasting (ADF) may produce greater improvements in body composition, fat distribution, and/or the adipokine profile compared to daily calorie restriction (CR), but this has not been tested directly. In a pre-planned secondary analysis of a randomized controlled trial, we compared changes in the VAT:SAT ratio, FFM:total mass ratio, and the adipokine profile between ADF and CR.
Methods
Overweight and obese participants (n = 100) were randomized to 1) ADF (alternating every 24-h between consuming 25% or 125% of energy needs); 2) CR (consuming 75% of needs every day); or 3) control (consuming 100% of needs every day) for 24 wk.
Results
The VAT:SAT ratio did not change in any group. The FFM:total mass ratio increased in both ADF (0.03 ± 0.00) and CR (0.03 ± 0.01) compared to the control group (P < 0.01), with no differences between the intervention groups. Circulating leptin decreased in both the ADF group (-18 ± 6%) and CR group (-31 ± 10%) relative to the control group (P < 0.05), with no differences between the intervention groups. Circulating levels of adiponectin, resistin, IL-6, and TNF-α did not change in either intervention group relative to the control group.
Conclusion
ADF and CR similarly improve the FFM:total mass ratio and reduce leptin after a 24-wk intervention.
Trial registration
Clinicaltrials.gov, number NCT00960505.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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