Plasma Alkylresorcinol Metabolite, a Biomarker of Whole-Grain Wheat and Rye Intake, and Risk of Type 2 Diabetes and Impaired Glucose Regulation in a Chinese Population
Sun T, Rong Y, Hu X, Zhu Y, Huang H, Chen L, Li P, Li S, Yang W, Cheng J, Yang X, Yao P, Hu FB, Liu L
Diabetes care · 22 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Biomarcadores de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundamental Research Funds for the Central Universities
- Gobierno
- Technique Innovation Program (Major Program) of Hubei Province of China
- Universidad u hospital
- Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College, Huazhong University of Science and Technology
- Subvenciones
- Fundamental Research Funds for the Central Universities (HUST 2016YXMS219)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2017-12-20 · Diabetes Care · vol. 41 · número 3 · págs. 440–445
- Editorial
- American Diabetes Association
- Citado
- 32 citas · más que el 90% de estudios similares · 2.6× el promedio de su campo
- Referencias
- 41 trabajos
- Acceso
- De pago
- Áreas de investigación
- Food composition and properties · Metabolomics and Mass Spectrometry Studies · Liver Disease Diagnosis and Treatment
- Palabras clave
- Medicine, Internal medicine, Type 2 diabetes, Diabetes mellitus, Odds ratio, Body mass index, Family history, Quartile, Population, Biomarker, Endocrinology, Confidence interval, Biology, Environmental health
- MeSH
- humans, triticum, diabetes mellitus, type 2, glucose intolerance, phenylpropionates, resorcinols, diet, risk factors, case-control studies, prospective studies, adult, aged, middle aged, china, female, male, biomarkers, secale
14 autores
- Taoping Sun🇨🇳Huazhong University of Science and Technology
- Rong Ying🇨🇳Shandong University; Shandong Provincial Hospital
- Xiaoli Hu🇨🇳Huazhong University of Science and Technology
- Yalun Zhu🇨🇳Huazhong University of Science and Technology
- Hao Huang🇨🇳Huazhong University of Science and Technology
- Liangkai Chen🇨🇳Huazhong University of Science and Technology
- Peiyun Li🇨🇳Huazhong University of Science and Technology
- Shuzhen Li🇨🇳Huazhong University of Science and Technology
- Wei Qiang Yang🇨🇳Huazhong University of Science and Technology
- Jinquan Cheng🇨🇳Shenzhen Center for Disease Control and Prevention
- Xuefeng Yang🇨🇳Huazhong University of Science and Technology
- Ping Yao🇨🇳Huazhong University of Science and Technology
- Frank B. Hu🇺🇸 · autor de correspondenciaHarvard University
- Liegang Liu🇨🇳 · autor de correspondenciaHuazhong University of Science and Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To examine the association of plasma alkylresorcinol metabolite 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), a biomarker of whole-grain wheat and rye intake, with type 2 diabetes (T2D) and impaired glucose regulation (IGR) in a Chinese population.
Research design and methods
A total of 1,060 newly diagnosed T2D patients, 736 newly diagnosed IGR patients, and 1,443 control subjects with normal glucose tolerance were recruited in the case-control study. Plasma DHPPA concentrations were determined by high-performance liquid chromatography-tandem mass spectroscopy. Multivariate logistic regression analysis was used to evaluate the independent association of plasma DHPPA concentrations with the likelihood of T2D and IGR.
Results
After adjustment for age, sex, BMI, and family history of diabetes, the odds ratios (95% CI) of T2D and IGR were 0.57 (0.45, 0.73) and 0.66 (0.50, 0.85), respectively, comparing the lowest with the highest quartile of plasma DHPPA concentrations. Further adjustment for current smoking status, current alcohol consumption, physical activity, history of hypertension, and educational level did not change the observed association materially. Similar results were also obtained in T2D and IGR groups combined. The inverse association of plasma DHPPA with T2D persisted in stratified analyses according to age, sex, BMI, current smoking status, current alcohol consumption, physical activity, family history of diabetes, and history of hypertension.
Conclusions
These findings suggested that higher plasma DHPPA concentrations were associated with lower odds of T2D and IGR. Further studies are warranted to confirm these findings in prospective cohorts.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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