Magnesium intake and mortality due to liver diseases: Results from the Third National Health and Nutrition Examination Survey Cohort
Wu L, Zhu X, Fan L, Kabagambe EK, Song Y, Tao M, Zhong X, Hou L, Shrubsole MJ, Liu J, Dai Q
Scientific reports · 38 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Health and Human Services
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK-058404); National Cancer Institute (R01 CA202936)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-12-14 · Sci Rep · vol. 7 · número 1 · pág. 17913
- Editorial
- Nature Portfolio
- Citado
- 57 citas · más que el 89% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments
- Palabras clave
- National Health and Nutrition Examination Survey, Cohort, Medicine, Environmental health, Cohort study, Gerontology, Internal medicine, Population
- MeSH
- humans, fatty liver, magnesium deficiency, magnesium, nutrition surveys, nutritional status, adult, middle aged, united states, female, male
11 autores
- Lijun Wu🇨🇳Fudan University; Huashan Hospital
- Xiangzhu Zhu🇺🇸Vanderbilt University; Vanderbilt University Medical Center
- Lei Fan🇨🇳Shanghai University of Traditional Chinese Medicine; Longhua Hospital Shanghai University of Traditional Chinese Medicine
- Edmond Kato Kabagambe🇺🇸Vanderbilt University Medical Center
- Yiqing Song🇺🇸Indiana University – Purdue University Indianapolis
- Meng‐Hua Tao🇺🇸University of North Texas; University of North Texas Health Science Center
- Xiaosong Zhong🇨🇳Capital Medical University; Beijing Shijitan Hospital
- Lifang Hou🇺🇸Northwestern University
- Martha J. Shrubsole🇺🇸Vanderbilt University; Vanderbilt University Medical Center
- Jie Liu🇨🇳 · autor de correspondenciaFudan University; Huashan Hospital
- Qi Dai🇺🇸 · autor de correspondenciaVanderbilt University; Vanderbilt University Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
People with fatty liver disease are at high risk of magnesium deficiency. Meanwhile, low magnesium status is linked to both chronic inflammation and insulin resistance. However, no study has investigated the association between intake of magnesium and risk of mortality due to liver diseases. We evaluated the association between total magnesium intake and mortality due to liver diseases in the Third National Health and Nutrition Examination Study (NHANES III) cohort, which included 13,504 participants who completed liver ultrasound examination for hepatic steatosis. Overall magnesium intake was associated with a reduced risk of mortality due to liver disease at borderline significance (P = 0.05). In fully-adjusted analyses, every 100 mg increase in intake of magnesium was associated with a 49% reduction in the risk for mortality due to liver diseases. Although interactions between magnesium intake and alcohol use and hepatic steatosis at baseline were not significant (P > 0.05), inverse associations between magnesium intake and liver disease mortality were stronger among alcohol drinkers and those with hepatic steatosis. Our findings suggest higher intakes of magnesium may be associated with a reduced risk of mortality due to liver disease particularly among alcohol drinkers and those with hepatic steatosis. Further studies are warranted to confirm the findings.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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