Red and processed meat consumption and breast cancer: UK Biobank cohort study and meta-analysis
Anderson JJ, Darwis NDM, Mackay DF, Celis-Morales CA, Lyall DM, Sattar N, Gill JMR, Pell JP
European journal of cancer (Oxford, England : 1990) · 75 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Medical Research Council
- Universidad u hospital
- Glasgow University Paterson Endowment Fund
- Subvenciones
- Medical Research Council (MC_PC_12028)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2017-12-21 · Eur J Cancer · vol. 90 · págs. 73–82
- Editorial
- Elsevier BV
- Citado
- 103 citas · más que el 98% de estudios similares · 7.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 29 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-SA
- Áreas de investigación
- Nutritional Studies and Diet · Cancer Risks and Factors · Meat and Animal Product Quality
- Palabras clave
- breast cancer, red meat consumption, processed meat consumption, dietary risk factors, postmenopausal breast cancer, premenopausal breast cancer, UK Biobank, cancer incidence
- MeSH
- humans, breast neoplasms, diet, proportional hazards models, cohort studies, food handling, adult, aged, middle aged, female, red meat, united kingdom
8 autores
- Jana J. Anderson🇬🇧University of Glasgow
- Narisa Dewi Maulany Darwis🇬🇧University of Glasgow
- Daniel Mackay🇬🇧University of Glasgow
- Carlos A. Celis-Morales🇬🇧University of Glasgow
- Donald M. Lyall🇬🇧University of Glasgow
- Naveed A. Sattar🇬🇧University of Glasgow
- Jason M. R. Gill🇬🇧University of Glasgow
- Jill P. Pell🇬🇧 · autor de correspondenciaUniversity of Glasgow
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aim
Red and processed meat may be risk factors for breast cancer due to their iron content, administration of oestrogens to cattle or mutagens created during cooking. We studied the associations in UK Biobank and then included the results in a meta-analysis of published cohort studies.
Methods
UK Biobank, a general population cohort study, recruited participants aged 40-69 years. Incident breast cancer was ascertained via linkage to routine hospital admission, cancer registry and death certificate data. Univariate and multivariable Cox proportional hazard models were used to explore the associations between red and processed meat consumption and breast cancer. Previously published cohort studies were identified from a systematic review using PubMed and Ovid and a meta-analysis conducted using a random effects model.
Results
Over a median of 7 years follow-up, 4819 of the 262,195 women developed breast cancer. The risk was increased in the highest tertile (>9 g/day) of processed meat consumption (adjusted hazard ratio [HR] 1.21, 95% confidence interval [CI] 1.08-1.35, p = 0.001). Collation with 10 previous cohort studies provided data on 40,257 incident breast cancers in 1.65 million women. On meta-analysis, processed meat consumption was associated with overall (relative risk [RR] 1.06, 95% CI 1.01-1.11) and post-menopausal (RR 1.09, 95% CI 1.03-1.15), but not pre-menopausal (RR 0.99, 95% CI 0.88-1.10), breast cancer. In UK Biobank and the meta-analysis, red meat consumption was not associated with breast cancer (adjusted HR 0.99 95% CI 0.88-1.12 and RR 1.03, 95% CI 0.99-1.08, respectively).
Conclusions
Consumption of processed meat, but not red meat, may increase the risk of breast cancer.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.