Financiado en parte por Novo Nordisk, Novo Nordisk Fonden
Association between coffee or caffeine consumption and fecundity and fertility: a systematic review and dose-response meta-analysis
Lyngsø J, Ramlau-Hansen CH, Bay B, Ingerslev HJ, Hulman A, Kesmodel US
Clinical epidemiology · 42 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- Aarhus Universitet
- Gobierno
- European Food Safety Authority
- Universidad u hospital
- Danish Diabetes Academy
- Empresa
- Novo Nordisk
- Empresa
- Novo Nordisk Fonden
Según 5 financiadores declarados.
Publicación
- Publicado
- 2017-12-01 · Clin Epidemiol · vol. Volume 9 · págs. 699–719
- Editorial
- Dove Medical Press
- Citado
- 61 citas · más que el 72% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 120 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Coffee research and impacts · Ovarian function and disorders · Gestational Diabetes Research and Management
- Palabras clave
- Fecundity, Caffeine, Fertility, Medicine, Meta-analysis, Consumption (sociology), Demography, Traditional medicine, Internal medicine, Environmental health, Population, Social science
6 autores
- Julie Lyngsø🇩🇰Aarhus University
- Cecilia Høst Ramlau‐Hansen🇩🇰Aarhus University
- Bjørn Bay🇩🇰Regional Hospital Horsens
- Hans Jakob Ingerslev🇩🇰Aarhus University Hospital
- Ádám Hulmán🇩🇰Aarhus University; Danish Diabetes Academy
- Ulrik Schiøler Kesmodel🇩🇰Gentofte Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The aim was to investigate whether coffee or caffeine consumption is associated with reproductive endpoints among women with natural fertility (ie, time to pregnancy [TTP] and spontaneous abortion [SAB]) and among women in fertility treatment (ie, clinical pregnancy rate or live birth rate).
Design
This study was a systematic review and dose-response meta-analysis including data from case-control and cohort studies.
Methods
An extensive literature search was conducted in MEDLINE and Embase, with no time and language restrictions. Also, reference lists were searched manually. Two independent reviewers assessed the manuscript quality using the Newcastle-Ottawa Scale (NOS). A two-stage dose-response meta-analysis was applied to assess a potential association between coffee/caffeine consumption and the outcomes: TTP, SAB, clinical pregnancy, and live birth. Heterogeneity between studies was assessed using Cochrane Q-test and I2 statistics. Publication bias was assessed using Egger's regression test.
Results
The pooled results showed that coffee/caffeine consumption is associated with a significantly increased risk of SAB for 300 mg caffeine/day (relative risk [RR]: 1.37, 95% confidence interval [95% CI]: 1.19; 1.57) and for 600 mg caffeine/day (RR: 2.32, 95% CI: 1.62; 3.31). No association was found between coffee/caffeine consumption and outcomes of fertility treatment (based on two studies). No clear association was found between exposure to coffee/caffeine and natural fertility as measured by fecundability odds ratio (based on three studies) or waiting TTP (based on two studies).
Conclusion
Results from this meta-analysis support the growing evidence of an association between coffee/caffeine intake and the risk of SAB. However, viewing the reproductive capacity in a broader perspective, there seems to be little, if any, association between coffee/caffeine consumption and fecundity. In general, results from this study are supportive of a precautionary principle advised by health organizations such as European Food Safety Authority (EFSA) and World Health Organization (WHO), although the advised limit of a maximum of two to three cups of coffee/200-300 mg caffeine per day may be too high.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.