Effect of alternate day fasting on markers of bone metabolism: An exploratory analysis of a 6-month randomized controlled trial
Barnosky A, Kroeger CM, Trepanowski JF, Klempel MC, Bhutani S, Hoddy KK, Gabel K, Shapses SA, Varady KA
Nutrition and healthy aging · 30 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Universidad u hospital
- University of Illinois at Chicago
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (F32DK107157); National Heart, Lung, and Blood Institute (#T32 HL007034); National Heart, Lung, and Blood Institute (R01 HL); National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK-072476); National Institutes of Health (T32HL007034); National Institutes of Health (F32DK107157)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-10-29 · Nutr Healthy Aging · vol. 4 · número 3 · págs. 255–263
- Editorial
- IOS Press
- Citado
- 43 citas · más que el 83% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Genetics, Aging, and Longevity in Model Organisms
- Palabras clave
- Osteocalcin, Internal medicine, Bone remodeling, Endocrinology, Overweight, Bone mineral, Medicine, Randomized controlled trial, N-terminal telopeptide, Weight loss, Calorie restriction, Alkaline phosphatase, Body mass index, Obesity, Chemistry, Osteoporosis, Biochemistry
9 autores
- Adrienne Barnosky🇺🇸Wheaton Franciscan Healthcare; University of Illinois Chicago
- Cynthia M. Kroeger🇺🇸University of Alabama at Birmingham; University of Illinois Chicago
- John F. Trepanowski🇺🇸University of Illinois Chicago; Stanford University
- Monica C Klempel🇺🇸University of Illinois Chicago
- Surabhi Bhutani🇺🇸University of Illinois Chicago
- Kristin K. Hoddy🇺🇸University of Illinois Chicago
- Kelsey Gabel🇺🇸University of Illinois Chicago
- Sue A. Shapses🇺🇸Rutgers, The State University of New Jersey
- Krista A Varady🇺🇸 · autor de correspondenciaUniversity of Illinois Chicago
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Alternate day fasting (ADF) is a novel diet therapy that reduces body weight, but its effect on bone health remains unknown.
Objective
This study examined the impact of ADF versus traditional daily calorie restriction (CR) on markers of bone metabolism in a 6-month randomized controlled trial.
Methods
Overweight and obese subjects (n = 100) were randomized to 1 of 3 groups for 6 months: 1) ADF (25% energy intake fast day, alternated with 125% intake feast day; 2) CR (75% intake every day); or 3) control (usual intake every day).
Results
Body weight decreased similarly (P P < 0.01) in the CR group, with no change in the ADF or control group. When the data were sub-analyzed according to menopausal status, there were no differences between premenopausal or postmenopausal women for any marker of bone metabolism.
Conclusion
These findings suggest that 6 months of ADF does not have any deleterious impact on markers of bone metabolism in obese adults with moderate weight loss.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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