Serum total cholesterol and risk of cardiovascular and non-cardiovascular mortality in old age: a population-based study
Liang Y, Vetrano DL, Qiu C
BMC geriatrics · 42 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Karolinska Institutet
- Gobierno
- Vetenskapsrådet
- Gobierno
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- Gobierno
- Swedish Research Council
- Gobierno
- Swedish Research Council for Health, Working Life and Welfare
- Subvenciones
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd (2014–1382); Vetenskapsrådet (2015-02531); Karolinska Institutet (2016oste46263)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-12-01 · BMC Geriatr · vol. 17 · número 1 · pág. 294
- Editorial
- BioMed Central
- Citado
- 60 citas · más que el 97% de estudios similares · 5.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Cholesterol and Lipid Metabolism · Paraoxonase enzyme and polymorphisms
- Palabras clave
- total cholesterol, all-cause mortality, cardiovascular mortality, non-cardiovascular mortality, older adults, cholesterol-lowering drugs, inverse association, competing risks, APOE genotype, cognitive function, mobility limitations, cause-specific mortality, hypercholesterolemia, cardiovascular risk factors, lifestyle factors
- MeSH
- humans, cardiovascular diseases, cholesterol, population surveillance, cause of death, risk factors, cohort studies, longitudinal studies, follow-up studies, aging, aged, aged, 80 and over, middle aged, sweden, female, male, mobility limitation
3 autores
- Yajun Liang🇸🇪 · autor de correspondenciaStockholm University; Karolinska Institutet
- Davide Liborio Vetrano🇮🇹🇸🇪Università Cattolica del Sacro Cuore; Stockholm University; Karolinska Institutet
- Chengxuan Qiu🇨🇳🇸🇪 · autor de correspondenciaShandong University; Stockholm University; Karolinska Institutet; Shandong Provincial Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Whether the suggested inverse association between total cholesterol and mortality in old age varies according to cause of death and use of cholesterol medications remains to be elucidated. The aim of this study was to assess the associations of total cholesterol with cardiovascular and non-cardiovascular mortality in old age, and to explore whether their associations vary by use of cholesterol-lowering medications.
Methods
The study participants included 3090 older adults (age ≥ 60 years, 63.7% women) from a population-based cohort study, i.e., the Swedish National study on Aging and Care in Kungsholmen, Stockholm. At baseline (2001-2004), data on demographic factors, lifestyles, cardiovascular risk factors, use of medications, global cognitive function, mobility limitation, and apolipoprotein E genotype were collected through interviews, clinical examinations, laboratory tests as well as from the Swedish national patient register. Vital statistics data (e.g., date and causes of death) till December 31, 2011 for all participants were derived from Swedish cause of death register. Data were analyzed using Cox proportional hazards model for all-cause mortality and Fine-Gray competing risks regression model for cause-specific mortality controlling for multiple potential confounders.
Results
During 23,196 person-years of follow-up (median per person, 7.5 years), 1059 (34.3%) participants died. Compared to normal total cholesterol (<5.18 mmol/l), borderline-high (5.18-6.21 mmol/l) and high (≥6.22 mmol/l) total cholesterol were associated with a decreased risk of all-cause mortality, with the multiple-adjusted hazard ratio (95% confidence interval, CI) of 0.71 (0.61-0.83) and 0.68 (0.57-0.80), respectively (P for trend <0.001). The competing risk regression models revealed that the reduced all-cause mortality associated with high total cholesterol (≥6.22 mmol/l)) was mainly due to the reduced risk of non-cardiovascular mortality (hazard ratio = 0.67, 95% CI = 0.51-0.88). These associations were statistically evident only among individuals without use of cholesterol-lowering medications.
Conclusions
The inverse association between high total cholesterol and reduced all-cause mortality in older adults is primarily due to non-cardiovascular mortality, especially among those who are not treated with cholesterol-lowering medications.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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