Effects of Protein, Essential Amino Acids, B-Hydroxy B-Methylbutyrate, Creatine, Dehydroepiandrosterone and Fatty Acid Supplementation on Muscle Mass, Muscle Strength and Physical Performance in Older People Aged 60 Years and Over. A Systematic Review on the Literature
Beaudart C, Rabenda V, Simmons M, Geerinck A, Araujo De Carvalho I, Reginster JY, Amuthavalli Thiyagarajan J, Bruyère O
The journal of nutrition, health & aging · 32 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2017-06-01 · J Nutr Health Aging · vol. 22 · número 1 · págs. 117–130
- Editorial
- Springer Science+Business Media
- Citado
- 42 citas · más que el 41% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 56 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Muscle metabolism and nutrition · Nutrition and Health in Aging · Muscle Physiology and Disorders
- Palabras clave
- protein supplementation, essential amino acids, beta-hydroxy-beta-methylbutyrate, creatine supplementation, dehydroepiandrosterone, fatty acid supplementation, muscle mass, muscle strength, physical performance, older adults, sarcopenia, muscle health
- MeSH
- muscle, skeletal, humans, creatine, dehydroepiandrosterone, fatty acids, amino acids, essential, dietary proteins, exercise, dietary supplements, aged, aged, 80 and over, middle aged, female, male, muscle strength, resistance training, physical functional performance
8 autores
- Charlotte Beaudart🇧🇪University of Liège
- Véronique Rabenda🇧🇪University of Liège
- M. Simmons🇺🇸Des Moines University Osteopathic Medical Center; Des Moines University
- Anton Geerinck🇧🇪University of Liège
- Islène Araujo de Carvalho🇨🇭World Health Organization
- Jean‐Yves Reginster🇧🇪University of Liège
- Jotheeswaran Amuthavalli Thiyagarajan🇨🇭World Health Organization
- Olivier Bruyère🇧🇪 · autor de correspondenciaUniversity of Liège
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
The objective of this study was to perform a systematic review to investigate the effects protein, essential amino acids (EAA), β-hydroxy β-methylbutyrate (HMB), creatine, dehydroepiandrosterone (DHEA) and fatty acid supplementation on muscle mass, muscle strength and physical performance of elderly subjects.
Methods
Using the electronic databases MEDLINE and EMBASE we identified RCTs published until February 2016 which assessed the effects of these nutrient supplementation on muscle strength, muscle mass or physical performance. Study selection and data extraction were performed by two independent reviewers.
Results
Search strategy allowed us to identify 23 RCTs. Among them, four used proteins as nutritional supplement, seven EAAs, six creatine, four DHEA and finally, two HMB. From our systematic review, it seems that the effects of these supplementations on muscle health are rather limited. Only consistent effects of EAA supplementation on physical performance (3 out of the 4 RCTs using EAA supplementation found significant effect of this supplementation on physical performance) and HMB supplementation on muscle mass (all the 2 identified RCTs using HMB supplementation found significant effect of this supplementation on muscle mass) have been found across studies. No consistent effects were found for the other types of dietary supplementation. Because of the important limitations in study design, inconsistency and lack of directness, the overall quality of the evidence was judged to be low or very low using the GRADE system.
Conclusion
This systematic review showed a limited effect of nutritional supplementation on muscle mass, muscle power and physical function. Inconsistent positive effects were observed for some specific supplementations but the results only concerned one aspect of the muscle. Well designed and appropriately powered RCTs are needed to provide evidence for appropriate clinical recommendations.
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