A whole-grain diet reduces peripheral insulin resistance and improves glucose kinetics in obese adults: A randomized-controlled trial
Malin SK, Kullman EL, Scelsi AR, Haus JM, Filion J, Pagadala MR, Godin JP, Kochhar S, Ross AB, Kirwan JP
Metabolism: clinical and experimental · 64 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
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Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Research Resources
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCRR NIH HHS
- Gobierno
- NIH Research Resources
- Gobierno
- NIH
- Gobierno
- NCATS NIH HHS
- Subvenciones
- National Center for Advancing Translational Sciences (UL1-TR-000439); National Center for Research Resources (UL1RR024989); National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007319); National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK-020572)
Según 9 financiadores declarados.
Publicación
- Publicado
- 2018-01-03 · Metabolism · vol. 82 · págs. 111–117
- Editorial
- Elsevier BV
- Citado
- 82 citas · más que el 97% de estudios similares · 6.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Food composition and properties · Diabetes, Cardiovascular Risks, and Lipoproteins · Diet, Metabolism, and Disease
- Palabras clave
- whole grain diet, refined grains, insulin resistance, glucose kinetics, type 2 diabetes risk, obesity, metabolic flexibility, hepatic insulin resistance, postprandial blood glucose, glucose oxidation, glucose appearance rate, isocaloric diet
- MeSH
- humans, insulin resistance, obesity, glucose, blood glucose, treatment outcome, cross-over studies, double-blind method, dietary fiber, adult, female, male, whole grains
10 autores
- Steven K. Malin🇺🇸Cleveland Clinic
- Emily L. Kullman🇺🇸Cleveland Clinic
- Amanda R. Scelsi🇺🇸Cleveland Clinic
- Jacob M. Haus🇺🇸Cleveland Clinic
- Julianne Filion🇺🇸Cleveland Clinic
- Mangesh R. Pagadala🇺🇸Cleveland Clinic
- Jean‐Philippe Godin🇨🇭Nestlé (Switzerland)
- Sunil Kochhar🇨🇭Nestlé (Switzerland)
- Alastair B. Ross🇨🇭Nestlé (Switzerland)
- John P. Kirwan🇺🇸 · autor de correspondenciaCleveland Clinic
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Whole-grain intake is associated with lower risk of type 2 diabetes but the mechanisms are unclear.
Purpose
We tested the hypothesis that a WG diet reduces insulin resistance and improves glucose use in individuals at risk for type 2 diabetes compared with an isocaloric-matched refined-grain diet.
Methods
A double-blind, randomized, controlled, crossover trial of 14 moderately obese adults (Age, 38 ± 2 y; BMI, 34.0 ± 1.1 kg/m2). Insulin resistance and glucose metabolism was assessed using an oral glucose tolerance test combined with isotopic tracers of [6,6-2H2]-glucose and [U-13C]-glucose, and indirect calorimetry. Peripheral and hepatic insulin resistance was assessed as 1/(rate of disposal/insulin), and endogenous glucose rates of appearance (Ra) iAUC60-240 × insulin iAUC60-240, respectively. Both diets met ADA nutritional guidelines and contained either whole-grain (50 g per 1000 kcal) or equivalent refined-grain. All food was provided for 8 wk. with an 8-10 wk. washout period between diets.
Results
Post-prandial glucose tolerance, peripheral insulin sensitivity, and metabolic flexibility (insulin-stimulated - fasting carbohydrate oxidation) improvements were greater after whole-grain compared to the refined-grain diet (P a insulin resistance was reduced by both diets, while fasting glucose and exogenous glucose-meal were unchanged after both interventions. Changes in peripheral insulin resistance and metabolic flexibility correlated with improved glucose tolerance (P < 0.05).
Conclusion
Whole-grains reduced diabetes risk and the mechanisms appear to work through reduced post-prandial blood glucose and peripheral insulin resistance that were statistically linked to enhanced metabolic flexibility.
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