Metaanálisis2018

Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations

Hong J, Hatchell KE, Bradfield JP, Bjonnes A, Chesi A, Lai CQ, Langefeld CD, Lu L, Lu Y, Lutsey PL, Musani SK, Nalls MA, Robinson-Cohen C, Roizen JD, Saxena R, Tucker KL, Ziegler JT, Arking DE, Bis JC, Boerwinkle E, Bottinger EP, Bowden DW, Gilsanz V, Houston DK, Kalkwarf HJ, Kelly A, Lappe JM, Liu Y, Michos ED, Oberfield SE, Palmer ND, Rotter JI, Sapkota B, Shepherd JA, Wilson JG, Basu S, de Boer IH, Divers J, Freedman BI, Grant SFA, Hakanarson H, Harris TB, Kestenbaum BR, Kritchevsky SB, Loos RJF, Norris JM, Norwood AF, Ordovas JM, Pankow JS, Psaty BM, Sanghera DK, Wagenknecht LE, Zemel BS, Meigs J, Dupuis J, Florez JC, Wang T, Liu CT, Engelman CD, Billings LK

The Journal of clinical endocrinology and metabolism · 32 citas

Cómo se estudió

Diseño: Metaanálisis (indexado por PubMed)
Estudiado en: Personas
Resultado principal: Marcadores de salud y funcionamiento

Quién lo pagó

Financiación: Financiación independiente
Gobierno: National Institutes of Health
Gobierno: National Institute on Aging
Gobierno: National Heart, Lung, and Blood Institute
Gobierno: National Human Genome Research Institute
Gobierno: National Institute of Nursing Research
Gobierno: National Institute of General Medical Sciences
Gobierno: National Institute of Diabetes and Digestive and Kidney Diseases
Gobierno: National Institute of Environmental Health Sciences
Gobierno: U.S. National Library of Medicine
Gobierno: National Center for Research Resources
Gobierno: National Center for Advancing Translational Sciences
Gobierno: National Institute on Minority Health and Health Disparities
Gobierno: Eunice Kennedy Shriver National Institute of Child Health and Human Development
Gobierno: NHGRI NIH HHS
Gobierno: NHLBI NIH HHS
Gobierno: NIEHS NIH HHS
Gobierno: NICHD NIH HHS
Gobierno: NIDDK NIH HHS
Gobierno: NCATS NIH HHS
Gobierno: NIA NIH HHS
Gobierno: NCRR NIH HHS
Gobierno: NIGMS NIH HHS
Gobierno: NLM NIH HHS
Gobierno: NINR NIH HHS
Gobierno: NIH HHS
Subvenciones: National Heart, Lung, and Blood Institute (HHSN268201 100012C); National Heart, Lung, and Blood Institute (HHSN268201300050C); National Heart, Lung, and Blood Institute (HHSN268201100007I); National Institute on Aging (P01-AG-023394); National Heart, Lung, and Blood Institute (N01 HC085086); National Center for Advancing Translational Sciences (UL-1TR000124); National Heart, Lung, and Blood Institute (R01 HL103706); National Heart, Lung, and Blood Institute (U01-HL0-80295); National Heart, Lung, and Blood Institute (HHSN268201100007C); National Center for Advancing Translational Sciences (UL1TR000077); National Heart, Lung, and Blood Institute (R01-HL-087652); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK071891); National Heart, Lung, and Blood Institute (N01-HC095169); National Institute of General Medical Sciences (U54-GM-115428); National Heart, Lung, and Blood Institute (R01-HL059367); National Center for Advancing Translational Sciences (UL1-TR-000,040); Eunice Kennedy Shriver National Institute of Child Health and Human Development (K08 HD087964); National Heart, Lung, and Blood Institute (HHSN2682 01100008C); National Institute of Diabetes and Digestive and Kidney Diseases (K24DK080140); National Heart, Lung, and Blood Institute (R01-HL085251); National Heart, Lung, and Blood Institute (N01-HC-095165); National Heart, Lung, and Blood Institute (HH-SN-268201100006C); National Heart, Lung, and Blood Institute (HHSN268201100011C); National Heart, Lung, and Blood Institute (HHSN2682011-00005I); National Center for Research Resources (M0-1RR 007122); National Center for Advancing Translational Sciences (UL1-TR001079); National Institute on Aging (R01AG032098); National Heart, Lung, and Blood Institute (N01 HC085079); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK082766); National Heart, Lung, and Blood Institute (N01 HC095163); National Heart, Lung, and Blood Institute (R01-HL120393); Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD076321); National Heart, Lung, and Blood Institute (N01 HC085083); National Institute on Aging (R01 AG 023629); National Heart, Lung, and Blood Institute (R01-HL086694); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK078616); National Institute on Aging (P30AG017266); National Institute on Aging (R01-AG 028050); National Heart, Lung, and Blood Institute (HHSN2682011-00009I); National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK063491); National Heart, Lung, and Blood Institute (R56 HL124004); National Heart, Lung, and Blood Institute (N01 HC085080); National Heart, Lung, and Blood Institute (HHSN268201100005C); National Heart, Lung, and Blood Institute (HHSN 268200800007C); National Institutes of Health (1s10od018522-01); National Institute of Diabetes and Digestive and Kidney Diseases (U01DK078616); National Heart, Lung, and Blood Institute (N02 HL064278); National Heart, Lung, and Blood Institute (HHSN268201300048C); National Heart, Lung, and Blood Institute (HHSN268201100005G); National Center for Advancing Translational Sciences (UL1TR001881.); National Heart, Lung, and Blood Institute (HHSN268201100010C); National Heart, Lung, and Blood Institute (N01-HC-095159); National Heart, Lung, and Blood Institute (N01 HC095168); Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD056465); National Heart, Lung, and Blood Institute (U01 HL130114); National Heart, Lung, and Blood Institute (N01-HC-095162); National Heart, Lung, and Blood Institute (R01-HL096875); U.S. National Library of Medicine (T15LM007359); National Heart, Lung, and Blood Institute (R01 HL105756); National Institute of Diabetes and Digestive and Kidney Diseases (K12 DK094723); National Heart, Lung, and Blood Institute (N01-HC-095161); National Heart, Lung, and Blood Institute (HHSN268201100011I); National Heart, Lung, and Blood Institute (HHSN268201300049C); Eunice Kennedy Shriver National Institute of Child Health and Human Development (P 2CHD047873); National Heart, Lung, and Blood Institute (R01HL060919); National Heart, Lung, and Blood Institute (HHSN268201500003C); National Heart, Lung, and Blood Institute (HHSN26820150 0003I); National Center for Research Resources (UL1 RR025005.); National Heart, Lung, and Blood Institute (HHSN268201200036C); National Heart, Lung, and Blood Institute (HHSN26820 1100009C); National Heart, Lung, and Blood Institute (N01 HC095167); National Heart, Lung, and Blood Institute (P50-HL105185); National Heart, Lung, and Blood Institute (N01HC085082); National Institute on Aging (N01 AG062106); National Heart, Lung, and Blood Institute (R01HL061019); National Heart, Lung, and Blood Institute (N01-HC-095160); National Heart, Lung, and Blood Institute (N01 HC055222); National Heart, Lung, and Blood Institute (N01 HC095166); National Institute of Diabetes and Digestive and Kidney Diseases (T32 DK-007-028); National Heart, Lung, and Blood Institute (N01 HC095164); National Heart, Lung, and Blood Institute (HHSN2682011-00008I); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK085175); Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD058886); National Heart, Lung, and Blood Institute (R01-HL-103612); National Heart, Lung, and Blood Institute (N01 HC085081); National Human Genome Research Institute (U01HG007417); National Institute on Aging (R01-AG029364); National Institute of Environmental Health Sciences (P30ES013508); National Human Genome Research Institute (HHSN268200782096C); National Institute of Diabetes and Digestive and Kidney Diseases (K01 DK109019); National Heart, Lung, and Blood Institute (R01HL060944); National Institute on Aging (N01 AG062103); National Institute of Nursing Research (R01-NR-012459)); National Heart, Lung, and Blood Institute (R01 HL087641); National Human Genome Research Institute (U01-HG0-04402); National Institute on Aging (N01 AG062101); National Center for Advancing Translational Sciences (UL1TR001420)

Según 25 financiadores declarados.

Publicación

Publicado: 2018-01-09 · J Clin Endocrinol Metab · vol. 103 · número 4 · págs. 1380–1392
Editorial: Oxford University Press
Citado: 44 citas · más que el 94% de estudios similares · 3.8× el promedio de su campo
Impacto: Entre el 10 % más citado de su campo
Referencias: 30 trabajos
Acceso: Acceso abierto (copia en repositorio)
Áreas de investigación: Vitamin D Research Studies · Genetic Associations and Epidemiology · Nutrition, Genetics, and Disease
Palabras clave: Single-nucleotide polymorphism, Vitamin D and neurology, Genetic genealogy, Ancestry-informative marker, Genome-wide association study, Context (archaeology), Genetic association, vitamin D deficiency, Vitamin D-binding protein, SNP, Population, Genetic admixture, Genetics, Population stratification, Biology, Medicine, Demography, Gene, Internal medicine, Genotype, Environmental health
MeSH: humans, vitamin d deficiency, vitamin d, body mass index, gene frequency, polymorphism, single nucleotide, adolescent, adult, aged, middle aged, child, united states, female, male, genome-wide association study, young adult, genetic loci, hispanic or latino, white people, black or african american

DOI ↗PubMed Central ↗OpenAlex ↗

60 autores

Jaeyoung Hong🇺🇸Boston University
Kathryn E. Hatchell🇺🇸University of Wisconsin–Madison
Jonathan P. Bradfield🇺🇸Children's Hospital of Philadelphia
Andrew Bjonnes🇺🇸Massachusetts General Hospital
Alessandra Chesi🇺🇸Children's Hospital of Philadelphia
Chao‐Qiang Lai🇺🇸Tufts University
Carl D. Langefeld🇺🇸Wake Forest University
Lingyi Lu🇺🇸Wake Forest University
Yingchang Lu🇺🇸Icahn School of Medicine at Mount Sinai
Pamela L. Lutsey🇺🇸University of Minnesota
Solomon K. Musani🇺🇸University of Mississippi Medical Center
Mike A. Nalls🇺🇸National Institutes of Health; National Institute on Aging
Cassianne Robinson‐Cohen🇺🇸University of Washington
Jeffery D Roizen🇺🇸Children's Hospital of Philadelphia
Richa Saxena🇺🇸Massachusetts General Hospital
Katherine L. Tucker🇺🇸University of Massachusetts Lowell
Julie T. Ziegler🇺🇸Wake Forest University
Dan E. Arking🇺🇸Johns Hopkins University; Johns Hopkins Medicine
Joshua C Bis🇺🇸University of Washington
Eric Boerwinkle🇺🇸The University of Texas Health Science Center at Houston
Erwin P. Böttinger🇺🇸Icahn School of Medicine at Mount Sinai
Donald W. Bowden🇺🇸Wake Forest University
Vicente Gilsanz🇺🇸University of Southern California; Children's Hospital of Los Angeles
Denise K. Houston🇺🇸Wake Forest University
Heidi J. Kalkwarf🇺🇸Cincinnati Children's Hospital Medical Center
Andrea Kelly🇺🇸Children's Hospital of Philadelphia; University of Pennsylvania
Joan M. Lappe🇺🇸Creighton University
Yongmei Liu🇺🇸Wake Forest University
Erin D. Michos🇺🇸Johns Hopkins University; Johns Hopkins Medicine
Sharon E. Oberfield🇺🇸Columbia University Irving Medical Center
Nicholette D Palmer🇺🇸Wake Forest University
Jerome I. Rotter🇺🇸The Lundquist Institute; Harbor–UCLA Medical Center
Bishwa R. Sapkota🇺🇸University of Oklahoma Health Sciences Center
John A. Shepherd🇺🇸University of California, San Francisco
James G. Wilson🇺🇸Jackson Memorial Hospital; University of Mississippi Medical Center
Saonli Basu🇺🇸University of Minnesota
Ian H. de Boer🇺🇸University of Washington
Jasmin Divers🇺🇸Wake Forest University
Barry I. Freedman🇺🇸Wake Forest University
Struan F.A. Grant🇺🇸Children's Hospital of Philadelphia; University of Pennsylvania
Hakon Hakanarson🇺🇸Children's Hospital of Philadelphia; University of Pennsylvania
Tamara B. Harris🇺🇸National Institute on Aging
Bryan R. Kestenbaum🇺🇸University of Washington
Stephen B. Kritchevsky🇺🇸Wake Forest University
Ruth J. F. Loos🇺🇸Child Health and Development Institute; Icahn School of Medicine at Mount Sinai
Jill M. Norris🇺🇸Colorado School of Public Health; University of Colorado Denver
Arnita F. Norwood🇺🇸University of Mississippi Medical Center
José María Ordovás🇺🇸Tufts University
James S. Pankow🇺🇸University of Minnesota
Bruce M. Psaty🇺🇸Kaiser Permanente Washington Health Research Institute; University of Washington
Dharambir K. Sanghera🇺🇸University of Oklahoma Health Sciences Center
Lynne E. Wagenknecht🇺🇸Wake Forest University
Babette S Zemel🇺🇸Children's Hospital of Philadelphia; University of Pennsylvania
James B. Meigs🇺🇸Harvard University; Massachusetts General Hospital
Josée Dupuis🇺🇸Boston University; National Heart, Lung, and Blood Institute; Framingham Heart Study
José C. Florez🇺🇸Broad Institute; Harvard University; Massachusetts General Hospital
Thomas J. Wang🇺🇸Vanderbilt University
Ching‐Ti Liu🇺🇸Boston University
Corinne D. Engelman🇺🇸University of Wisconsin–Madison
Liana K. Billings🇺🇸 · autor de correspondenciaEndeavor Health; University of Chicago

Resumen

El texto original del estudio, en el idioma en que se publicó.

Context

Vitamin D inadequacy is common in the adult population of the United States. Although the genetic determinants underlying vitamin D inadequacy have been studied in people of European ancestry, less is known about populations with Hispanic or African ancestry.

Objective

The Trans-Ethnic Evaluation of Vitamin D (TRANSCEN-D) genomewide association study (GWAS) consortium was assembled to replicate genetic associations with 25-hydroxyvitamin D [25(OH)D] concentrations from the Study of Underlying Genetic Determinants of Vitamin D and Highly Related Traits (SUNLIGHT) meta-analyses of European ancestry and to identify genetic variants related to vitamin D concentrations in African and Hispanic ancestries.

Design

Ancestry-specific (Hispanic and African) and transethnic (Hispanic, African, and European) meta-analyses were performed with Meta-Analysis Helper software (METAL).

Patients or other participants

In total, 8541 African American and 3485 Hispanic American (from North America) participants from 12 cohorts and 16,124 European participants from SUNLIGHT were included in the study.

Main outcome measures

Blood concentrations of 25(OH)D were measured for all participants.

Results

Ancestry-specific analyses in African and Hispanic Americans replicated single nucleotide polymorphisms (SNPs) in GC (2 and 4 SNPs, respectively). An SNP (rs79666294) near the KIF4B gene was identified in the African American cohort. Transethnic evaluation replicated GC and DHCR7 region SNPs. Additionally, the transethnic analyses revealed SNPs rs719700 and rs1410656 near the ANO6/ARID2 and HTR2A genes, respectively.

Conclusions

Ancestry-specific and transethnic GWASs of 25(OH)D confirmed findings in GC and DHCR7 for African and Hispanic American samples and revealed findings near KIF4B, ANO6/ARID2, and HTR2A. The biological mechanisms that link these regions with 25(OH)D metabolism warrant further investigation.

Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.

Leer el texto completo ↗Ver en PubMed ↗

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