Alp Rose stem cells, olive oil squalene and a natural alkyl polyglucoside emulsifier: Are they appropriate ingredients of skin moisturizers - in vivo efficacy on normal and sodium lauryl sulfate - irritated skin?
Filipović M, Gledović A, Lukić M, Tasić-Kostov M, Isailović T, Pantelić I, Vuleta G, Savić S
Vojnosanitetski pregled · 3 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
- Gobierno
- Ministry of Education, Science and Technological Development of the Republic of Serbia
- Subvenciones
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (TR 34031)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2016-01-01 · Vojnosanit Pregl · vol. 73 · número 11 · págs. 991–1002
- Editorial
- Military Health Department, Ministry of Defance, Serbia
- Citado
- 13 citas · más que el 84% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 20 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-SA
- Áreas de investigación
- Contact Dermatitis and Allergies · Advancements in Transdermal Drug Delivery · Dermatology and Skin Diseases
- Palabras clave
- emollients, skin irritation, sodium dodecyl sulfate, skin barrier, transepidermal water loss, skin hydration, erythema, viscoelasticity, liposomes, cosmetic dermatology
- MeSH
- stem cells, skin, humans, rhododendron, plants, medicinal, sodium dodecyl sulfate, squalene, glucosides, liposomes, emulsifying agents, phytotherapy, administration, cutaneous, risk assessment, double-blind method, skin irritancy tests, consumer product safety, water loss, insensible, viscosity, elasticity, time factors, adult, female, serbia, young adult, skin cream, olive oil
8 autores
- Mila Filipović
- Ana Gledović🇷🇸University of Belgrade
- Milica Ž. Lukić🇷🇸University of Belgrade
- Marija Tasić Kostov🇷🇸University of Nis
- Tanja M. Isailović🇷🇸University of Belgrade
- Ivana Pantelić🇷🇸University of Belgrade
- Gordana M. Vuleta🇷🇸University of Belgrade
- Snezana D. Savic🇷🇸University of Belgrade
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/aim
Since skin moisturization may be achieved by both actives and chosen carrier, plant stem cells, squalene and natural alkyl polyglucoside emulsifier may be potential components of contemporary cosmetic products. The aim of the study was in vivo evaluation of the skin irritation potential and the efficacy of Alpine Rose stem cells incorporated into li-posomes and olive oil squalene as ingredients of moisturizing creams, with respect to the novel emulsifier used for creams’ stabilization.
Methods
With the employment of noninvasive skin biophysical measurements, skin hydration (EC), transepi-dermal water loss (TEWL), erythema index (EI) and viscoelas-ticity were measured on 76 healthy volunteers. In the first phase, skin irritation after a 24-hour occlusion and the long-term efficacy of creams (a 21-day study) on healthy skin were evaluated. Phase II of the study focused on the cream efficacy assessment after a 6-day treatment of sodium lauryl sulfate-irritated skin.
Results
After a 24-hour occlusion, there were no significant changes in the EI for any tested sample. In the second phase of the study, the EI was not significantly altered for the cream containing squalene, while the application of all active samples resulted in a significant reduction of TEWL. In both phases of the study an EC increase was recorded, espe-cially for the squalene-containing cream.
Conclusion
Due to the lack of skin irritation and skin barrier impairment along with the marked hydration effect, it could be said that the in-vestigated actives incorporated into alkyl polyglucoside emulsi-fier-stabilized creams may be safely applied as ingredients for "tailor-made" cosmetic moisturizers intended for normal and dry skin care, whereas olive oil squalene could be used for the treatment of irritated or sensitive skin as well. [Projekat Ministarstva nauke Republike Srbije, br. TR34031]
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-SA).
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