Comparing olive oil and C4-dietary oil, a prodrug for the GPR119 agonist, 2-oleoyl glycerol, less energy intake of the latter is needed to stimulate incretin hormone secretion in overweight subjects with type 2 diabetes
Mandøe MJ, Hansen KB, Windeløv JA, Knop FK, Rehfeld JF, Rosenkilde MM, Holst JJ, Hansen HS
Nutrition & diabetes · 14 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministério da Ciência, Tecnologia e Inovação
- Organización sin fines de lucro
- Augustinus Fonden
- Universidad u hospital
- NNF Center for Basic Metabolic Research
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-01-08 · Nutr Diabetes · vol. 8 · número 1 · pág. 2
- Editorial
- Springer Nature
- Citado
- 26 citas · más que el 91% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 62 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Diabetes Treatment and Management · Regulation of Appetite and Obesity · Fatty Acid Research and Health
- Palabras clave
- olive oil, GPR119 agonists, incretin secretion, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, 2-monoacylglycerols, dietary fat, type 2 diabetes, overweight, postprandial hormone response, energy intake, dietary fat restriction, triglycerides
- MeSH
- humans, diabetes mellitus, type 2, obesity, glycerol, gastric inhibitory polypeptide, dietary fats, unsaturated, oleic acid, glycerides, triglycerides, receptors, g-protein-coupled, prodrugs, area under curve, single-blind method, postprandial period, aged, middle aged, female, male, overweight, glucagon-like peptide 1, incretins, meals, olive oil
8 autores
- Mette Johannsen Mandøe🇩🇰University of Copenhagen; Novo Nordisk Foundation; Glostrup Hospital; Novo Nordisk Foundation Center for Basic Metabolic Research
- Katrine Bagge Hansen🇩🇰University of Copenhagen; Novo Nordisk Foundation; Glostrup Hospital; Novo Nordisk Foundation Center for Basic Metabolic Research
- Johanne Agerlin Windeløv🇩🇰University of Copenhagen; Novo Nordisk Foundation; Novo Nordisk Foundation Center for Basic Metabolic Research
- Filip Krag Knop🇩🇰University of Copenhagen; Novo Nordisk Foundation; Gentofte Hospital; Novo Nordisk Foundation Center for Basic Metabolic Research
- Jens Frederik Rehfeld🇩🇰University of Copenhagen; Rigshospitalet
- METTE MARIE ROSENKILDE🇩🇰University of Copenhagen
- Jens Juul Holst🇩🇰 · autor de correspondenciaUniversity of Copenhagen; Novo Nordisk Foundation; Novo Nordisk Foundation Center for Basic Metabolic Research
- Harald Severin Hansen🇩🇰University of Copenhagen
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/objective
After digestion, dietary triacylglycerol stimulates incretin release in humans, mainly through generation of 2-monoacylglycerol, an agonist for the intestinal G protein-coupled receptor 119 (GPR119). Enhanced incretin release may have beneficial metabolic effects. However, dietary fat may promote weight gain and should therefore be restricted in obesity. We designed C4-dietary oil (1,3-di-butyryl-2-oleoyl glycerol) as a 2-oleoyl glycerol (2-OG)-generating fat type, which would stimulate incretin release to the same extent while providing less calories than equimolar amounts of common triglycerides, e.g., olive oil.
Subjects and methods
We studied the effect over 180 min of (a) 19 g olive oil plus 200 g carrot, (b) 10.7 g C4 dietary oil plus 200 g carrot and (c) 200 g carrot, respectively, on plasma responses of gut and pancreatic hormones in 13 overweight patients with type 2 diabetes (T2D). Theoretically, both oil meals result in formation of 7.7 g 2-OG during digestion.
Results
Both olive oil and C4-dietary oil resulted in greater postprandial (P ≤ 0.01) glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) responses (incremental area under curve (iAUC)): iAUCGLP-1: 645 ± 194 and 702 ± 97 pM × min; iAUCGIP: 4,338 ± 764 and 2,894 ± 601 pM × min) compared to the carrot meal (iAUCGLP-1: 7 ± 103 pM × min; iAUCGIP: 266 ± 234 pM × min). iAUC for GLP-1 and GIP were similar for C4-dietary oil and olive oil, although olive oil resulted in a higher peak value for GIP than C4-dietary oil.
Conclusion
C4-dietary oil enhanced secretion of GLP-1 and GIP to almost the same extent as olive oil, in spite of liberation of both 2-OG and oleic acid, which also may stimulate incretin secretion, from olive oil. Thus, C4-dietary oil is more effective as incretin releaser than olive oil per unit of energy and may be useful for dietary intervention.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.