Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial
Wang W, Yu WY, Lv J, Chen LH, Li Z
The Journal of international medical research · 5 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Government of Jiangsu Province
- Universidad u hospital
- Nanjing Medical University
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-01-14 · J Int Med Res · vol. 46 · número 3 · págs. 1063–1072
- Editorial
- SAGE Publishing
- Citado
- 6 citas · más que el 59% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 28 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Anesthesia and Sedative Agents · Anesthesia and Pain Management · Enhanced Recovery After Surgery
- Palabras clave
- bispectral index, postoperative recovery, elderly patients, general anesthesia, extubation, post-anesthesia care unit
- MeSH
- humans, propofol, phosphocreatine, anesthetics, intravenous, anesthesia, general, anesthesia recovery period, cholecystectomy, laparoscopic, double-blind method, consciousness, aged, aged, 80 and over, female, male, delayed emergence from anesthesia, consciousness monitors, airway extubation
5 autores
- Wei Ting Wang🇨🇳Nanjing Jiangning Hospital; Nanjing Medical University
- Wanyou Yu🇨🇳Nanjing Jiangning Hospital; Nanjing Medical University
- Jie Lv🇨🇳Nanjing Jiangning Hospital; Nanjing Medical University
- Lianhua Chen🇨🇳Shanghai First People's Hospital; Nanjing Medical University
- Zhong Li🇨🇳 · autor de correspondenciaNanjing Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective To evaluate the effect of creatine phosphate sodium on bispectral index (BIS) and recovery quality during the general anaesthesia emergence period in elderly patients. Methods This randomized, double-blind, placebo-controlled study enrolled patients undergoing transabdominal cholecystectomy under general anaesthesia. Patients were randomly assigned to receive either creatine phosphate sodium (1.0 g/100 ml 0.9% saline; group P) or 100 ml 0.9% saline (group C) over 30 minutes during surgical incision. The BIS values were recorded at anaesthesia induction (T0), skin incision (T1), cutting the gallbladder (T2), suturing the peritoneum (T3), skin closure (T4), sputum suction (T5), extubation (T6) and 1 min (T7), 5 min (T8), 10 min (T9), and 15 min (T10) after extubation. The anaesthesia duration, operation time, waking time, extubation time, consciousness recovery time, time in the postanaesthesia care unit (PACU), and the Steward recovery scores at T7, T8, T9 and T10 were recorded. Results A total of 120 elderly patients were randomized equally to the two groups. Compared with group C, the BIS values were significantly higher in group P at T5, T6, T7 and T8; and the Steward recovery scores at T7 and T8 were significantly higher in group P. The waking time, extubation time, consciousness recovery time and time in the PACU were significantly shorter in group P compared with group C. Conclusion Creatine phosphate sodium administered during transabdominal cholecystectomy can improve BIS values and recovery following general anaesthesia in elderly patients.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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