Association between circulating 25-hydroxyvitamin D levels and psoriasis, and correlation with disease severity: a meta-analysis
Lee YH, Song GG
Clinical and experimental dermatology · 31 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2018-01-16 · Clin Exp Dermatol · vol. 43 · número 5 · págs. 529–535
- Editorial
- Oxford University Press
- Citado
- 59 citas · más que el 76% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 24 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Psoriasis: Treatment and Pathogenesis · Bone health and osteoporosis research
- Palabras clave
- Psoriasis, Psoriasis Area and Severity Index, Medicine, Internal medicine, Vitamin D and neurology, Correlation, Gastroenterology, Pathogenesis, Severity of illness, Endocrinology, Immunology
- MeSH
- humans, psoriasis, vitamin d, severity of illness index, case-control studies
2 autores
- Young Ho Lee🇰🇷 · autor de correspondenciaKorea University
- Gwan Gyu Song🇰🇷Korea University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Psoriasis is a chronic, autoimmune, inflammatory skin disorder. 25-hydroxy vitamin D [25(OH)D] deficiency may contribute to the pathogenesis of psoriasis through reduction in antiproliferative, anti-inflammatory and antiangiogenic activities.
Aim
To evaluate the relationship between circulating 25(OH)D levels and psoriasis, and to determine the correlation between serum/plasma 25(OH)D levels and psoriasis severity.
Methods
We performed a meta-analysis to compare serum/plasma 25(OH)D levels between patients with psoriasis and healthy controls (HCs), and to determine the correlation coefficients between circulating 25(OH)D levels and psoriasis severity as assessed by Psoriasis Area and Severity Index (PASI).
Results
Ten articles with a total of 571 patients with psoriasis and 496 HCs were included. The 25(OH)D level was significantly lower in the psoriasis group than in the HC group. Subgroup analysis by sample size revealed a significantly lower level of 25(OH)D in the psoriasis group for large (N > 80) but not for small (N < 80) sample sizes. Stratification by adjustment for age and/or sex or sample type revealed a significantly lower 25(OH)D level in the psoriasis group after adjustment for serum but not after nonadjustment for plasma. Meta-analysis of the correlation coefficients revealed a small but statistically significant positive correlation between circulating 25(OH)D levels and PASI.
Conclusions
This meta-analysis demonstrated that circulating 25(OH)D levels are lower in patients with psoriasis, and that a small but statistically significant negative correlation exists between 25(OH)D levels and psoriasis severity.
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