Dietary nitrate-induced increases in human muscle power: high versus low responders
Coggan AR, Broadstreet SR, Mikhalkova D, Bole I, Leibowitz JL, Kadkhodayan A, Park S, Thomas DP, Thies D, Peterson LR
Physiological reports · 62 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Foundation for Barnes-Jewish Hospital
- Universidad u hospital
- Institute of Clinical and Translational Sciences
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCATS NIH HHS
- Universidad u hospital
- Washington University Institute of Clinical and Translational Sciences
- Universidad u hospital
- Washington University Mentors in Medicine and C-STAR programs
- Subvenciones
- Institute of Clinical and Translational Sciences (UL1TR000448); National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK056341); National Center for Advancing Translational Sciences (UL1-TR-000448); Foundation for Barnes-Jewish Hospital (UL1 TR000448); National Center for Advancing Translational Sciences (UL1TR002345); National Center for Advancing Translational Sciences (TR000448); National Institutes of Health (UL1‐TR000448); National Institutes of Health (TR000448)
Según 9 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-01-01 · Physiol Rep · vol. 6 · número 2 · pág. e13575
- Editorial
- Wiley
- Citado
- 70 citas · más que el 99% de estudios similares · 10.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Cardiovascular and exercise physiology · Exercise and Physiological Responses · Muscle metabolism and nutrition
- Palabras clave
- Placebo, Crossover study, Medicine, Internal medicine, Nitric oxide, Body mass index, Bioavailability, Dietary Nitrate, Endocrinology, Nitrite, Animal science, Cardiology, Nitrate, Chemistry, Biology, Pharmacology, Pathology
- MeSH
- humans, beta vulgaris, plant roots, nitrates, nitric oxide, cross-over studies, double-blind method, dietary supplements, adult, aged, middle aged, female, male, athletic performance, muscle fibers, skeletal, young adult, fruit and vegetable juices
10 autores
- Andrew R. Coggan🇺🇸 · autor de correspondenciaUniversity of Indianapolis; Washington University in St. Louis; Indiana University – Purdue University Indianapolis
- Seth R. Broadstreet🇺🇸University of Indianapolis; Indiana University – Purdue University Indianapolis
- Deana Mikhalkova🇺🇸Washington University in St. Louis
- Indra Bole🇺🇸Washington University in St. Louis
- Joshua L. Leibowitz🇺🇸Washington University in St. Louis
- Ana Kadkhodayan🇺🇸Washington University in St. Louis
- Soohyung Park🇺🇸Washington University in St. Louis
- Deepak P. Thomas🇺🇸Washington University in St. Louis
- Dakkota Thies🇺🇸Washington University in St. Louis
- Linda R. Peterson🇺🇸Washington University in St. Louis
Resumen
El texto original del estudio, en el idioma en que se publicó.
Maximal neuromuscular power is an important determinant of athletic performance and also quality of life, independence, and perhaps even mortality in patient populations. We have shown that dietary nitrate (NO3- ), a source of nitric oxide (NO), improves muscle power in some, but not all, subjects. The present investigation was designed to identify factors contributing to this interindividual variability. Healthy men (n = 13) and women (n = 7) 22-79 year of age and weighing 52.1-114.9 kg were studied using a randomized, double-blind, placebo-controlled, crossover design. Subjects were tested 2 h after ingesting beetroot juice (BRJ) either containing or devoid of 12.3 ± 0.8 mmol of NO3- . Plasma NO3- and nitrite (NO2- ) were measured as indicators of NO bioavailability and maximal knee extensor speed (Vmax ), power (Pmax ), and fatigability were determined via isokinetic dynamometry. On average, dietary NO3- increased (P max by 4.4 ± 8.1%. Individual changes, however, ranged from -9.6 to +26.8%. This interindividual variability was not significantly correlated with age, body mass (inverse of NO3- dose per kg), body mass index (surrogate for body composition) or placebo trial Vmax or fatigue index (in vivo indicators of muscle fiber type distribution). In contrast, the relative increase in Pmax was significantly correlated (r = 0.60; P 2- concentration. In multivariable analysis female sex also tended (P = 0.08) to be associated with a greater increase in Pmax. We conclude that the magnitude of the dietary NO3- -induced increase in muscle power is dependent upon the magnitude of the resulting increase in plasma NO2- and possibly female sex.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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