Cashew Nut Consumption Increases HDL Cholesterol and Reduces Systolic Blood Pressure in Asian Indians with Type 2 Diabetes: A 12-Week Randomized Controlled Trial
Mohan V, Gayathri R, Jaacks LM, Lakshmipriya N, Anjana RM, Spiegelman D, Jeevan RG, Balasubramaniam KK, Shobana S, Jayanthan M, Gopinath V, Divya S, Kavitha V, Vijayalakshmi P, Bai R MR, Unnikrishnan R, Sudha V, Krishnaswamy K, Salas-Salvadó J, Willett WC
The Journal of nutrition · 50 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2018-01-01 · J Nutr · vol. 148 · número 1 · págs. 63–69
- Editorial
- Elsevier BV
- Citado
- 84 citas · más que el 98% de estudios similares · 7.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- Anacardium occidentale, type 2 diabetes, HDL cholesterol, systolic blood pressure, Asian Indians, oleic acid, monounsaturated fatty acids, glycemic control, lipid profile, body weight, diabetic diet
- MeSH
- humans, anacardium, nuts, cardiovascular diseases, diabetes mellitus, type 2, cholesterol, blood glucose, triglycerides, body mass index, treatment outcome, patient compliance, blood pressure, adult, middle aged, india, female, male, cholesterol, hdl, white people
20 autores
- Viswanathan Mohan🇮🇳 · autor de correspondenciaMadras Diabetes Research Foundation
- Rajagopal Gayathri🇮🇳Madras Diabetes Research Foundation
- Lindsay M. Jaacks
- Nagarajan Lakshmipriya🇮🇳Madras Diabetes Research Foundation
- Ranjit Mohan Anjana🇮🇳Madras Diabetes Research Foundation
- Donna L. Spiegelman🇺🇸Harvard University
- Raman Ganesh Jeevan🇮🇳Madras Diabetes Research Foundation
- K Kandappa Gounder Balasubramaniam🇮🇳Madras Diabetes Research Foundation
- Shanmugam Shobana🇮🇳Madras Diabetes Research Foundation
- Mathialagan Jayanthan🇮🇳Madras Diabetes Research Foundation
- Viswanathan Gopinath🇮🇳Madras Diabetes Research Foundation
- Selvakumar Divya🇮🇳Madras Diabetes Research Foundation
- Vasudevan Kavitha🇮🇳Madras Diabetes Research Foundation
- Parthasarathy Vijayalakshmi🇮🇳Madras Diabetes Research Foundation
- Mookambika Ramya Bai R🇮🇳Madras Diabetes Research Foundation
- Ranjit Unnikrishnan I🇮🇳Madras Diabetes Research Foundation
- Vasudevan Sudha🇮🇳Madras Diabetes Research Foundation
- Kamala Krishnaswamy🇮🇳Madras Diabetes Research Foundation
- Jordi Salas‐Salvadó🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Institut de Recerca Biomèdica Catalunya Sud; Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili
- Walter Churchill Willett🇺🇸Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
There is increasing evidence that nut consumption decreases the risk of cardiovascular disease. However, there are few data on the health effects of cashew nuts among adults with type 2 diabetes (T2DM).
Objective
The study aimed to investigate the effects of cashew nut supplementation on glycemia, body weight, blood pressure, and lipid profile in Asian Indians with T2DM.
Methods
In a parallel-arm, randomized controlled trial, 300 adults with T2DM [mean ± SD age: 51 ± 9.3 y; body mass index (BMI; in kg/m2): 26.0 ± 3.4; 55% male] were randomly assigned to receive advice to follow a standard diabetic diet (control) or similar advice plus 30 g cashew nuts/d (intervention) for 12 wk. The macronutrient composition of the prescribed diabetic diet was 60-65% energy from carbohydrates, 15-25% from fat, and the rest from protein. Differences between groups in changes in anthropometric and biochemical variables were analyzed using linear models with robust variance estimation under an assumed independence working correlation.
Results
Participants in the intervention group had a greater decrease in systolic blood pressure from baseline to 12 wk than did controls (-4.9 ± 13.7 compared with -1.7 ± 11.6 mm Hg; P = 0.04) and a greater increase in plasma HDL cholesterol compared with controls (+1.7 ± 5.6 compared with +0.1 ± 4.6 mg/dL; P = 0.01). There were no differences between the groups with respect to changes in body weight, BMI, blood lipid, and glycemic variables. Plasma oleic acid concentrations and self-reported dietary intake of nuts, oleic acid, and monounsaturated fatty acids suggested excellent compliance with the nut consumption.
Conclusion
Cashew nut supplementation in Asian Indians with T2DM reduced systolic blood pressure and increased HDL cholesterol concentrations with no deleterious effects on body weight, glycemia, or other lipid variables. This study was registered at the clinical trial registry of India as CTRI/2017/07/009022.
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