Acute ingestion of dietary nitrate increases muscle blood flow via local vasodilation during handgrip exercise in young adults
Richards JC, Racine ML, Hearon CM, Kunkel M, Luckasen GJ, Larson DG, Allen JD, Dinenno FA
Physiological reports · 44 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (indexado por PubMed)
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- Resultado principal
- Marcadores de salud y funcionamiento
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Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-01-01 · Physiol Rep · vol. 6 · número 2 · pág. e13572
- Editorial
- Wiley
- Citado
- 60 citas · más que el 99% de estudios similares · 10.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Cardiovascular and exercise physiology · Heart Rate Variability and Autonomic Control · Nitric Oxide and Endothelin Effects
- Palabras clave
- Ingestion, Vasodilation, Medicine, Blood flow, Cardiology, Internal medicine, Dietary Nitrate, Nitrate, Chemistry
- MeSH
- muscle, skeletal, humans, beta vulgaris, plant roots, nitrates, nitrites, hand strength, exercise, oxygen consumption, regional blood flow, vasodilation, dietary supplements, adult, female, male, hemodynamics, fruit and vegetable juices
8 autores
- Jennifer C. Richards🇺🇸Colorado State University
- Matthew L. Racine🇺🇸Colorado State University
- Christopher M. Hearon🇺🇸Colorado State University
- Megan J. Kunkel🇺🇸Colorado State University
- Gary J. Luckasen🇺🇸Valley Health System
- Dennis G. Larson🇺🇸Valley Health System
- Jason David Allen🇺🇸Duke University; University of Virginia
- Frank A. Dinenno🇺🇸 · autor de correspondenciaColorado State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary nitrate (NO3-) is converted to nitrite (NO2-) and can be further reduced to the vasodilator nitric oxide (NO) amid a low O2 environment. Accordingly, dietary NO3- increases hind limb blood flow in rats during treadmill exercise; however, the evidence of such an effect in humans is unclear. We tested the hypothesis that acute dietary NO3- (via beetroot [BR] juice) increases forearm blood flow (FBF) via local vasodilation during handgrip exercise in young adults (n = 11; 25 ± 2 years). FBF (Doppler ultrasound) and blood pressure (Finapres) were measured at rest and during graded handgrip exercise at 5%, 15%, and 25% maximal voluntary contraction (MVC) lasting 4 min each. At the highest workload (25% MVC), systemic hypoxia (80% SaO2 ) was induced and exercise continued for three additional minutes. Subjects ingested concentrated BR (12.6 mmol nitrate (n = 5) or 16.8 mmol nitrate (n = 6) and repeated the exercise bout either 2 (12.6 mmol) or 3 h (16.8 mmol) postconsumption. Compared to control, BR significantly increased FBF at 15% MVC (184 ± 15 vs. 164 ± 15 mL/min), 25% MVC (323 ± 27 vs. 286 ± 28 mL/min), and 25% + hypoxia (373 ± 39 vs. 343 ± 32 mL/min) and this was due to increases in vascular conductance (i.e., vasodilation). The effect of BR on hemodynamics was not different between the two doses of BR ingested. Forearm VO2 was also elevated during exercise at 15% and 25% MVC. We conclude that acute increases in circulating NO3- and NO2- via BR increases muscle blood flow during moderate- to high-intensity handgrip exercise via local vasodilation. These findings may have important implications for aging and diseased populations that demonstrate impaired muscle perfusion and exercise intolerance.
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