Financiado en parte por Danone Institute of Canada
A high whey protein, vitamin D and E supplement preserves muscle mass, strength, and quality of life in sarcopenic older adults: A double-blind randomized controlled trial
Bo Y, Liu C, Ji Z, Yang R, An Q, Zhang X, You J, Duan D, Sun Y, Zhu Y, Cui H, Lu Q
Clinical nutrition (Edinburgh, Scotland) · 141 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Danone Institute of Canada
Según 1 financiador declarado.
Publicación
- Publicado
- 2018-01-09 · Clin Nutr · vol. 38 · número 1 · págs. 159–164
- Editorial
- Elsevier BV
- Citado
- 183 citas · más que el 98% de estudios similares · 8.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nutrition and Health in Aging · Muscle metabolism and nutrition · Muscle Physiology and Disorders
- Palabras clave
- sarcopenia, older adults, whey protein, vitamin D, vitamin E, dietary supplementation, muscle mass, muscle strength, grip strength, physical function, quality of life, insulin-like growth factor I, interleukin-2, walking speed, Timed Up and Go test, frailty, falls, bioimpedance
- MeSH
- muscle, skeletal, humans, vitamin e, vitamins, vitamin d, double-blind method, quality of life, dietary supplements, aged, aged, 80 and over, middle aged, female, male, muscle strength, sarcopenia, whey proteins
12 autores
- Yacong Bo🇨🇳Zhengzhou University
- Changfeng Liu🇨🇳First Affiliated Hospital of Zhengzhou University
- Zhe Ji
- Ruihong Yang
- Qianqian An
- Xueyuan Zhang🇨🇳Zhengzhou University
- Jie You🇨🇳Zhengzhou University
- Dandan Duan🇨🇳Zhengzhou University
- Yafei Sun🇨🇳Zhengzhou University
- Yiwei Zhu🇨🇳Zhengzhou University
- Han Cui🇨🇳Zhengzhou University
- Quanjun Lü🇨🇳 · autor de correspondenciaZhengzhou University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Sarcopenia, an age-related decline of muscle mass, strength, and physical function, was associated with falls, frailty, and poor quality of life. The aim of the current study is to examine the effect of nutritional supplement containing whey protein, vitamin D and E on measures of sarcopenia.
Methods
A total of 60 sarcopenic older adult subjects participated in the current randomized, double-blind, placebo-controlled (iso-caloric control product) trial for 6 months. Muscle mass [Relative skeletal mass index (RSMI) measured by bioimpedance analysis (BIA)], muscle strength (handgrip strength), physical function (6-m gait speed, chair stand test, and timed-up-and-go test, TUG), quality of life (measured by Short-Form 36-Item Health Survey, SF-36), and blood biochemical indexes were measured before and after the 6-month intervention.
Results
Compared to placebo group, nutritional supplementation improves RSMI (mean difference: 0.18 kg/m2, 95%CI: 0.01-0.35, P = 0.040), handgrip strength (mean difference: 2.68 kg, 95%CI: 0.71-4.65, P = 0.009), SF-36 mental component summary (SF-36 MCS) (mean difference: 11.26, 95%CI: 3.86-18.65, P = 0.004), SF-36 physical component summary (SF-36 PCS) (mean difference: 20.21, 95%CI: 11.30-29.12, P 3 (mean difference: 11.01 ng/mL, 95%CI: 6.44-15,58, P < 0.001), and serum vitamin E (mean difference: 4.17 ng/L, 95%CI: 1.89-6.45, P = 0.001).
Conclusion
The current study demonstrated that the combined supplementation of whey protein, vitamin D and E can significantly improve RSMI, muscle strength, and anabolic markers such as IGF-I and IL-2 in older adults with sarcopenia. Further larger well-designed studies are warranted to evaluate whether long-term whey protein supplementation can blunt the declines of muscle function and mass in older adults with sarcopenia.
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