Financiado en parte por Research Grant for Rhododendrol Vitiligo Researches sponsored by Kanebo Cosmetics
Efficacy of oral cholecalciferol on rhododendrol-induced vitiligo: A blinded randomized clinical trial
Watabe A, Yamasaki K, Asano M, Kanbayashi Y, Nasu-Tamabuchi M, Terui H, Furudate S, Kakizaki A, Tsuchiyama K, Kimura Y, Ito Y, Kikuchi K, Aiba S
The Journal of dermatology · 14 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Research Grant for Rhododendrol Vitiligo Researches sponsored by Kanebo Cosmetics
Según 1 financiador declarado.
Publicación
- Publicado
- 2018-02-05 · J Dermatol · vol. 45 · número 4 · págs. 456–462
- Editorial
- Wiley
- Citado
- 19 citas · más que el 73% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 40 trabajos
- Acceso
- De pago
- Áreas de investigación
- melanin and skin pigmentation · Atherosclerosis and Cardiovascular Diseases · Mast cells and histamine
- Palabras clave
- Vitiligo, Medicine, Randomized controlled trial, Vitamin D and neurology, Cholecalciferol, Clinical trial, Vitamin, Internal medicine, Gastroenterology, Dermatology
- MeSH
- skin, humans, vitiligo, butanols, cholecalciferol, calcifediol, vitamins, photography, treatment outcome, administration, oral, adult, aged, middle aged, female, skin lightening preparations
13 autores
- Akiko Watabe🇯🇵Tohoku University
- Kenshi Yamasaki🇯🇵 · autor de correspondenciaTohoku University
- Masayuki Asano🇯🇵Tohoku University
- Yumi Kanbayashi🇯🇵Tohoku University
- Mei Nasu‐Tamabuchi🇯🇵Tohoku University
- Hitoshi Terui🇯🇵Tohoku University
- Sadanori Furudate🇯🇵Tohoku University
- Aya Kakizaki🇯🇵Tohoku University
- Kenichiro Tsuchiyama🇯🇵Tohoku University
- Yutaka Kimura🇯🇵Tohoku University
- Yumiko Ito🇯🇵Tohoku University
- Katsuko Kikuchi🇯🇵Tohoku University
- Setsuya Aiba🇯🇵Tohoku University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Rhododendrol (RD), 4-(4-hydroxyphenyl)-2-butanol, inhibits melanin synthesis and has been used for skin-whitening cosmetic products. RD has been very effective in lightening skin pigmentation, but some persons have developed so-called RD vitiligo, in which vitiligo starts on the face, neck and hands where topical RD has been applied and even extended over skin areas where RD has not been applied. RD vitiligo lesions in some patients have lasted for years and have been resistant to conventional vitiligo treatments. We examined the effects of cholecalciferol on RD vitiligo in a blinded randomized clinical trial. Forty-eight female RD vitiligo patients were recruited for the trial and were randomized into two groups: the vitamin D (VD)-intervention group that received daily 5000 IU cholecalciferol for 5 months and the control group. Three blinded investigators scored vitiligo improvement by comparing photographic images of baseline and at 5-month observation. Serum 25(OH)D3 of RD vitiligo patients was not significantly different from age-matched healthy volunteers. Twenty-two in the VD-intervention group and 23 in the control group completed the 5-month observation. Serum 25(OH)D3 levels were significantly increased after the 5-month VD intervention, while the control group did not change. The improvement scores were significantly higher in the VD-intervention group than the control group. The improvement scores were positively correlated with the serum 25(OH)D3 levels after the 5-month intervention period but not before the treatment. This blinded randomized clinical trial showed favor in administrating 5000 IU cholecalciferol daily to RD vitiligo patients.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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