Music Intervention Leads to Increased Insular Connectivity and Improved Clinical Symptoms in Schizophrenia
He H, Yang M, Duan M, Chen X, Lai Y, Xia Y, Shao J, Biswal BB, Luo C, Yao D
Frontiers in neuroscience · 37 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Chengdu Science and Technology Bureau
- Gobierno
- Health and Family Planning Commission of Sichuan Province
- Subvenciones
- National Natural Science Foundation of China (ZYGX2015J091); National Natural Science Foundation of China (16PJ051); National Natural Science Foundation of China (2013YQ490859); Chengdu Science and Technology Bureau (2013-11); National Natural Science Foundation of China (81330032); National Natural Science Foundation of China (B12027); National Natural Science Foundation of China (2013-11); National Natural Science Foundation of China (81471638); National Natural Science Foundation of China (2017JY0094)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2018-01-23 · Front Neurosci · vol. 11 · pág. 744
- Editorial
- Frontiers Media
- Citado
- 104 citas · más que el 99% de estudios similares · 9.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 88 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Functional Brain Connectivity Studies · Neuroscience and Music Perception · Music Therapy and Health
- Palabras clave
- Schizophrenia (object-oriented programming), Intervention (counseling), Music therapy, Psychology, Antipsychotic, Insula, Functional magnetic resonance imaging, Medicine, Psychiatry, Neuroscience
10 autores
- Hui He🇨🇳University of Electronic Science and Technology of China
- Mi Yang🇨🇳University of Electronic Science and Technology of China
- Mingjun Duan🇨🇳University of Electronic Science and Technology of China
- Xi Chen🇨🇳University of Electronic Science and Technology of China
- Yongxiu Lai🇨🇳University of Electronic Science and Technology of China
- Yang Xia🇨🇳University of Electronic Science and Technology of China
- Junming Shao🇨🇳University of Electronic Science and Technology of China
- Bharat B. Biswal🇨🇳University of Electronic Science and Technology of China
- Cheng Luo🇨🇳 · autor de correspondenciaUniversity of Electronic Science and Technology of China
- Dezhong Yao🇨🇳 · autor de correspondenciaUniversity of Electronic Science and Technology of China
Resumen
El texto original del estudio, en el idioma en que se publicó.
Schizophrenia is a syndrome that is typically accompanied by delusions and hallucinations that might be associated with insular pathology. Music intervention, as a complementary therapy, is commonly used to improve psychiatric symptoms in the maintenance stage of schizophrenia. In this study, we employed a longitudinal design to assess the effects of listening to Mozart music on the insular functional connectivity (FC) in patients with schizophrenia. Thirty-six schizophrenia patients were randomly divided into two equal groups as follows: the music intervention (MTSZ) group, which received a 1-month music intervention series combined with antipsychotic drugs, and the no-music intervention (UMTSZ) group, which was treated solely with antipsychotic drugs. Resting-state functional magnetic resonance imaging (fMRI) scans were performed at the following three timepoints: baseline, 1 month after baseline and 6 months after baseline. Nineteen healthy participants were recruited as controls. An FC analysis seeded in the insular subregions and machine learning techniques were used to examine intervention-related changes. After 1 month of listening to Mozart music, the MTSZ showed increased FC in the dorsal anterior insula (dAI) and posterior insular (PI) networks, including the dAI-ACC, PI-pre/postcentral cortices, and PI-ACC connectivity. However, these enhanced FCs had vanished in follow-up visits after 6 months. Additionally, a support vector regression on the FC of the dAI-ACC at baseline yielded a significant prediction of relative symptom remission in response to music intervention. Furthermore, the validation analyses revealed that 1 month of music intervention could facilitate improvement of the insular FC in schizophrenia. Together, these findings revealed that the insular cortex could potentially be an important region in music intervention for patients with schizophrenia, thus improving the patients' psychiatric symptoms through normalizing the salience and sensorimotor networks.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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