Caffeine and seizures: A systematic review and quantitative analysis
van Koert RR, Bauer PR, Schuitema I, Sander JW, Visser GH
Epilepsy & behavior : E&B · 57 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Gobierno
- UK Department of Health's National Institute for Health Research Biomedical Research Centers
- Gobierno
- National Institute for Health Research (NIHR)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2018-02-03 · Epilepsy Behav · vol. 80 · págs. 37–47
- Editorial
- Elsevier BV
- Citado
- 86 citas · más que el 78% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 111 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC-ND
- Áreas de investigación
- Epilepsy research and treatment · Coffee research and impacts · Pharmacological Effects and Toxicity Studies
- Palabras clave
- caffeine, seizures, epilepsy, antiepileptic drugs, drug interactions, topiramate, seizure susceptibility, seizure protection, animal models of epilepsy
- MeSH
- animals, humans, epilepsy, seizures, caffeine, anticonvulsants, central nervous system stimulants, drug interactions
5 autores
- Rick R. van Koert🇳🇱Leiden University
- Prisca Rachel Bauer🇬🇧🇳🇱National Institute for Health and Care Research; UCL Biomedical Research Centre; National Hospital for Neurology and Neurosurgery; Stichting Epilepsie Instellingen Nederland; UCL Queen Square Institute of Neurology; University College London
- Ilse Schuitema🇳🇱Leiden University
- Josemir W. A. S. Sander🇬🇧🇳🇱 · autor de correspondenciaNational Institute for Health and Care Research; UCL Biomedical Research Centre; National Hospital for Neurology and Neurosurgery; Stichting Epilepsie Instellingen Nederland; UCL Queen Square Institute of Neurology; University College London; Epilepsy Society
- Gerhard H. Visser🇳🇱Stichting Epilepsie Instellingen Nederland
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Caffeine is the most commonly used central nervous system (CNS) stimulant. The relationship between caffeine, seizures, epilepsy, and antiepileptic drugs (AEDs) is complex and not fully understood. Case reports suggest that caffeine triggers seizures in susceptible people. Our systematic review reports on the relationship between caffeine, seizures, and drugs in animal and human studies. Quantitative analyses were also done on animal studies regarding the effects of caffeine on AEDs.
Methods
PubMed was searched for studies assessing the effects of caffeine on seizure susceptibility, epilepsy, and drug interactions in people and in animal models. To quantify the interaction between AEDs and caffeine, the data of six animal studies were pooled and analyzed using a general linear model univariate analysis or One-way Analysis of Variance (ANOVA).
Results
In total, 442 items were identified from which we included 105 studies. Caffeine can increase seizure susceptibility and protect from seizures, depending on the dose, administration type (chronic or acute), and the developmental stage at which caffeine exposure started. In animal studies, caffeine decreased the antiepileptic potency of some drugs; this effect was strongest in topiramate.
Conclusion
Preclinical studies suggest that caffeine increases seizure susceptibility. In some cases, chronic use of caffeine may protect against seizures. Caffeine lowers the efficacy of several drugs, especially topiramate. It is unclear how these findings in models can be translated to the clinical condition. Until clinical studies suggest otherwise, caffeine intake should be considered as a factor in achieving and maintaining seizure control in epilepsy.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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