Efficacy of photodynamic therapy or low level laser therapy against steroid therapy in the treatment of erosive-atrophic oral lichen planus
Mirza S, Rehman N, Alrahlah A, Alamri WR, Vohra F
Photodiagnosis and photodynamic therapy · 49 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Deanship of Scientific Research, King Saud University
Según 1 financiador declarado.
Publicación
- Publicado
- 2018-02-06 · Photodiagnosis Photodyn Ther · vol. 21 · págs. 404–408
- Editorial
- Elsevier BV
- Citado
- 74 citas · más que el 97% de estudios similares · 6.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral Health Pathology and Treatment · Laser Applications in Dentistry and Medicine · Oral health in cancer treatment
- Palabras clave
- photodynamic therapy, low-level laser therapy, topical corticosteroids, toluidine blue, GaAlAs laser, diode laser, oral lesions, pain, treatment efficacy
- MeSH
- humans, lichen planus, oral, tolonium chloride, dexamethasone, anti-inflammatory agents, photosensitizing agents, photochemotherapy, severity of illness index, adult, aged, middle aged, female, male, lasers, semiconductor, low-level light therapy
5 autores
- Sana Mirza🇵🇰Ziauddin University
- Navedur Rehman
- Ali A. Alrahlah🇸🇦King Saud University
- Wa’ad Rafa Alamri🇸🇦King Saud University
- Fahim Ahmed Vohra🇸🇦 · autor de correspondenciaKing Saud University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The efficacy of photodynamic therapy (PDT) or low level laser therapy (LLLT) in the treatment of oral lichen planus (OLP) is debatable. The aim of this study was to compare the effects of PDT, LLLT or topical corticosteroid application in the treatment of erosive-atrophic OLP.
Materials and methods
Forty-five adult patients with erosive-atrophic biopsy-proven OLP on the tongue or buccal mucosa (size ≤3 cm) were randomly divided into three groups. Group-1: patients receiving PDT topical application of 50 μl toluidine blue (1 mg/ml) with micropipette and after 10 min treated by laser irradiation using GaAlAs laser (630 nm, 10 mW/cm2, continuous wave, spot size: 1 cm2); Group-2: patients receiving LLLT using diode laser (630 nm, 10 mW, continuous wave, spot size: 1 cm2); and Group-3: patients receiving topical corticosteroid applications consisting of dexamethasone (0.5 mg in 5 ml water) mouthwash for 5 min. Demographic data, type, and severity of the lesions and pain were recorded before and after treatment and then at the 1 year follow-up.
Results
There was a significant difference in sign score changes before and after the treatment in the PDT group (p = 0.03), LLLT group (p = 0.04) and in the control group (p = 0.02). There was a statistically significant difference between group-1 (p = 0.001) and group-2 (p = 0.001) against group-3 before and after treatment. Mean amount of improvement in pain was significantly greater in the control group in comparison with the PDT and LLLT groups (p < 0.001). The efficacy index of the PDT group improved significantly more than the LLLT (p = 0.001) and corticosteroid groups (p = 0.001).
Conclusion
Within the limits of the present RCT, it is indicated that PDT and LLLT are effective in the treatment of erosive-atrophic forms of OLP in adult patients. However, further comparative clinical trials are needed to obtain strong conclusions in this regard.
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