l-Theanine and caffeine improve target-specific attention to visual stimuli by decreasing mind wandering: a human functional magnetic resonance imaging study
Kahathuduwa CN, Dhanasekara CS, Chin SH, Davis T, Weerasinghe VS, Dassanayake TL, Binks M
Nutrition research (New York, N.Y.) · 26 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Texas Tech University
- Universidad u hospital
- Neuroimaging Seed Grant of the College of Human Sciences, Texas Tech University
Según 2 financiadores declarados.
Publicación
- Publicado
- 2017-11-17 · Nutr Res · vol. 49 · págs. 67–78
- Editorial
- Elsevier BV
- Citado
- 40 citas · más que el 76% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 60 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Mind wandering and attention · Sleep and Work-Related Fatigue
- Palabras clave
- theanine, caffeine, mind wandering, visual attention, distractor processing, target detection, neural resource allocation, synergistic effect, dietary supplements
- MeSH
- humans, caffeine, glutamates, central nervous system stimulants, magnetic resonance imaging, cross-over studies, cognition, attention, drug synergism, reference values, dietary supplements, adolescent, adult, male, young adult
7 autores
- Chanaka Nadeeshan Kahathuduwa🇱🇰🇺🇸University of Peradeniya; Texas Tech University
- Chathurika Samudani Dhanasekara🇺🇸Texas Tech University
- Shao-Hua Chin🇺🇸Texas Tech University
- Tyler H. Davis🇺🇸Texas Tech University
- Vajira Senaka Weerasinghe🇱🇰University of Peradeniya
- Tharaka L. Dassanayake🇱🇰🇦🇺University of Peradeniya; University of Newcastle Australia
- Martin Binks🇺🇸 · autor de correspondenciaTexas Tech University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Oral intake of l-theanine and caffeine supplements is known to be associated with faster stimulus discrimination, possibly via improving attention to stimuli. We hypothesized that l-theanine and caffeine may be bringing about this beneficial effect by increasing attention-related neural resource allocation to target stimuli and decreasing deviation of neural resources to distractors. We used functional magnetic resonance imaging (fMRI) to test this hypothesis. Solutions of 200mg of l-theanine, 160mg of caffeine, their combination, or the vehicle (distilled water; placebo) were administered in a randomized 4-way crossover design to 9 healthy adult men. Sixty minutes after administration, a 20-minute fMRI scan was performed while the subjects performed a visual color stimulus discrimination task. l-Theanine and l-theanine-caffeine combination resulted in faster responses to targets compared with placebo (∆=27.8milliseconds, P=.018 and ∆=26.7milliseconds, P=.037, respectively). l-Theanine was associated with decreased fMRI responses to distractor stimuli in brain regions that regulate visual attention, suggesting that l-theanine may be decreasing neural resource allocation to process distractors, thus allowing to attend to targets more efficiently. l-Theanine-caffeine combination was associated with decreased fMRI responses to target stimuli as compared with distractors in several brain regions that typically show increased activation during mind wandering. Factorial analysis suggested that l-theanine and caffeine seem to have a synergistic action in decreasing mind wandering. Therefore, our hypothesis is that l-theanine and caffeine may be decreasing deviation of attention to distractors (including mind wandering); thus, enhancing attention to target stimuli was confirmed.
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