Green leafy and cruciferous vegetable consumption and risk of type 2 diabetes: results from the Singapore Chinese Health Study and meta-analysis
Chen GC, Koh WP, Yuan JM, Qin LQ, van Dam RM
The British journal of nutrition · 42 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- National University of Singapore
- Gobierno
- China Scholarship Council
- Gobierno
- National Institutes of Health
- Gobierno
- Medical Research Council
- Gobierno
- National Medical Research Council
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Subvenciones
- Medical Research Council (NMRC/CSA/0055/2013); National Cancer Institute (R01CA144034); National Institutes of Health (NIH-R01); National Medical Research Council (NMRC/CSA/0055/2013); National Cancer Institute (UM1 CA182876); National Institutes of Health (UM1CA182876); National Institutes of Health (CA182876); National Institutes of Health (R01-CA144034); National Institutes of Health (NIH R01 CA144034); National Institutes of Health (R01 CA144034 and UM1 CA182876); National Institutes of Health (CA144034)
Según 7 financiadores declarados.
Publicación
- Publicado
- 2018-02-19 · Br J Nutr · vol. 119 · número 9 · págs. 1057–1067
- Editorial
- Cambridge University Press
- Citado
- 55 citas · más que el 92% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Consumer Attitudes and Food Labeling · Diet and metabolism studies
- Palabras clave
- Cruciferous vegetables, Medicine, Hazard ratio, Type 2 diabetes, Environmental health, Lower risk, Confounding, Prospective cohort study, Proportional hazards model, Relative risk, Population, Demography, Diabetes mellitus, Confidence interval, Internal medicine, Endocrinology, Cancer
- MeSH
- humans, brassicaceae, vegetables, diabetes mellitus, type 2, diet, risk factors, feeding behavior, aged, middle aged, singapore, female, male, asian people
5 autores
- Guo‐Chong Chen🇸🇬🇨🇳National University of Singapore; Soochow University
- Woon‐Puay Koh🇸🇬National University of Singapore; Duke-NUS Medical School; National University Health System
- Jian‐Min Yuan🇺🇸University of Pittsburgh; UPMC Hillman Cancer Center
- Li‐Qiang Qin🇨🇳Soochow University
- Rob M. van Dam🇸🇬 · autor de correspondenciaNational University of Singapore; National University Health System
Resumen
El texto original del estudio, en el idioma en que se publicó.
Several previous prospective studies suggest that consumption of green leafy and cruciferous vegetables may lower the risk of type 2 diabetes (T2D). We investigated the association between consumption of different types of vegetables in relation to T2D risk in an Asian Population. We included 45 411 participants (age range: 45-74 years) of the Singapore Chinese Health Study (SCHS) free of diabetes, cancer or CVD at baseline (1993-1998). Dietary information was collected using a validated FFQ. Physician-diagnosed incident diabetes was reported at follow-up I (1999-2004) and II (2006-2010) interviews. Cox proportional hazards regression was used to estimate hazard ratio (HR) and 95 % CI of T2D risk. An updated meta-analysis was also conducted to summarise results for green leafy and cruciferous vegetables. During 494 741 person-years of follow-up, 5207 incident T2D occurred. After adjustment for potential confounders, neither total vegetables (top v. bottom quintile HR=1·08; 95 % CI 0·98, 1·18, P trend=0·66) nor specific vegetables including dark green leafy vegetables (HR=1·05; 95 % CI 0·96, 1·15, P trend=0·21) and cruciferous vegetables (HR=0·97; 95 % CI 0·88, 1·06, P trend=0·29) were substantially associated with risk of T2D. A meta-analysis (eleven studies with 754 729 participants and 58 297 cases) including the SCHS and all previous prospective studies suggested borderline significant inverse associations between green leafy (summary relative risk (RR)=0·91; 95 % CI 0·84, 1·00) and cruciferous vegetable consumption (RR=0·87; 95 % CI 0·76, 1·00) and T2D risk, with moderate-to-high heterogeneity. In conclusion, green leafy or cruciferous vegetable consumption was not substantially associated with risk of T2D in an Asian population. Meta-analysis of available cohort data indicated that evidence for a beneficial effect of green leafy or cruciferous vegetable consumption on T2D risk is not convincing.
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