Cognitive response to fish oil, blueberry, and combined supplementation in older adults with subjective cognitive impairment
McNamara RK, Kalt W, Shidler MD, McDonald J, Summer SS, Stein AL, Stover AN, Krikorian R
Neurobiology of aging · 103 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Subvenciones
- National Institute on Aging (R01 AG034617)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2017-12-11 · Neurobiol Aging · vol. 64 · págs. 147–156
- Editorial
- Elsevier BV
- Citado
- 140 citas · más que el 98% de estudios similares · 6.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 87 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Dementia and Cognitive Impairment Research · Nutritional Studies and Diet
- Palabras clave
- fish oil supplementation, eicosapentaenoic acid, docosahexaenoic acid, anthocyanins, subjective cognitive impairment, older adults, memory discrimination, erythrocyte fatty acids, combination supplementation, cognitive aging
- MeSH
- humans, anthocyanins, glycosides, docosahexaenoic acids, eicosapentaenoic acid, fish oils, prospective studies, double-blind method, cognition, memory, dietary supplements, aged, middle aged, female, male, blueberry plants, cognitive dysfunction
8 autores
- Robert K. McNamara🇺🇸University of Cincinnati; University of Cincinnati Medical Center
- Wilhelmina Kalt🇨🇦Agriculture and Agri-Food Canada; Kentville Research and Development Centre
- Marcelle D. Shidler🇺🇸University of Cincinnati; University of Cincinnati Medical Center
- Jane E. McDonald🇨🇦Agriculture and Agri-Food Canada; Kentville Research and Development Centre
- Suzanne S. Summer🇺🇸Cincinnati Children's Hospital Medical Center
- Amanda L. Stein🇺🇸University of Cincinnati; University of Cincinnati Medical Center
- Amanda Nicole Stover🇺🇸University of Cincinnati; University of Cincinnati Medical Center
- Robert Krikorian🇺🇸 · autor de correspondenciaUniversity of Cincinnati; University of Cincinnati Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Given evidence that eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and anthocyanin-rich blueberries provide neurocognitive benefit, we investigated long-term supplementation in older adults with cognitive complaints. In a 24-week randomized, double-blind, placebo-controlled trial, elderly men and women received daily fish oil (FO) or blueberry (BB) or both. Diet records confirmed that participants reduced background consumption of EPA, DHA, and anthocyanins as prescribed. Erythrocyte EPA + DHA composition increased in the FO groups (p = 0.0001). Total urinary anthocyanins did not differ between the groups after supplementation but glycoside and native (food) forms increased only in the BB-supplemented groups. The FO (p = 0.03) and BB (p = 0.05) groups reported fewer cognitive symptoms, and the BB group showed improved memory discrimination (p = 0.04), indicating that supplementation improved cognition. Cognitive benefit in the BB group was associated with the presence of urinary anthocyanins reflecting recent BB intake but not with anthocyanin metabolites. However, combined FO + BB treatment was not associated with cognitive enhancement as expected.
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