Lower Vitamin D Status Is Associated with an Increased Risk of Ischemic Stroke: A Systematic Review and Meta-Analysis
Zhou R, Wang M, Huang H, Li W, Hu Y, Wu T
Nutrients · 91 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (81230066)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-02-28 · Nutrients · vol. 10 · número 3 · pág. 277
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 115 citas · más que el 92% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Vitamin K Research Studies
- Palabras clave
- vitamin D status, ischemic stroke, hemorrhagic stroke, stroke risk factors, vitamin D deficiency, vitamin D supplementation
- MeSH
- humans, brain ischemia, vitamin d deficiency, vitamin d, prognosis, odds ratio, risk factors, chi-square distribution, stroke, biomarkers
6 autores
- Ren Zhou🇨🇳Peking University
- Mengying Wang🇨🇳Peking University
- Hui Huang🇨🇳Peking University
- Wenyong Li🇨🇳Peking University
- Yonghua Hu🇨🇳Peking University
- Tao Wu🇨🇳 · autor de correspondenciaPeking University
Resumen
El texto original del estudio, en el idioma en que se publicó.
In recent years, accumulating evidence has supported the hypothesis that lower vitamin D status is associated with several known risk factors of stroke. However, the relationship between vitamin D and stroke is still uncertain. To explore if there was an association between vitamin D status and the risk of stroke, a systematic review and a meta-analysis were conducted by searching three databases: Pubmed, Embase, and the Cochrane Library. Following the application of inclusion and exclusion criteria, the relative risk estimates of all the included studies were pooled together to compare the risk of stroke between the lowest and the highest category of vitamin D. The Newcastle-Ottawa Scale (NOS) and the Cochrane Risk of Bias Tool were used to assess the risk of bias, and the publication bias was detected by using a funnel plot and Egger's test. Nineteen studies were included and the pooled relative risk was 1.62 (95% CI: 1.34-1.96). Further analysis found that vitamin D status was associated with ischemic stroke (relative risk = 2.45, 95% CI: 1.56-3.86), but not with hemorrhagic stroke (relative risk = 2.50, 95% CI: 0.87-7.15). In conclusion, our meta-analysis supported the hypothesis that lower vitamin D status was associated with an increased risk of ischemic stroke. Further studies are required to confirm this association and to explore the association among different subtypes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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