Association between serum 25-hydroxyvitamin D concentration and pulmonary infection in children
Li W, Cheng X, Guo L, Li H, Sun C, Cui X, Zhang Q, Song G
Medicine · 17 citas
Cómo se estudió
- Diseño
- Estudio de casos y controles (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-01-01 · Medicine (Baltimore) · vol. 97 · número 1 · pág. e9060
- Editorial
- Wolters Kluwer
- Citado
- 38 citas · más que el 93% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 30 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-ND
- Áreas de investigación
- Vitamin D Research Studies · Chronic Obstructive Pulmonary Disease (COPD) Research · Vitamin C and Antioxidants Research
- Palabras clave
- Medicine, Pneumonia, Sepsis, Internal medicine, Vitamin D and neurology, Gastroenterology, Community-acquired pneumonia, Multiple organ dysfunction syndrome, Mechanical ventilation
- MeSH
- humans, community-acquired infections, sepsis, pneumonia, vitamin d deficiency, vitamin d, case-control studies, roc curve, seasons, nutritional status, adolescent, child, child, preschool, infant, infant, newborn, female, male
8 autores
- Wěi Li🇨🇳Children's Hospital of Capital Institute of Pediatrics
- Xianfen Cheng
- Linying Guo🇨🇳 · autor de correspondenciaChina-Japan Friendship Hospital; Children's Hospital of Capital Institute of Pediatrics
- Hongri Li🇨🇳Children's Hospital of Capital Institute of Pediatrics
- Chunrong Sun
- Xiaodai Cui
- Qi Zhang🇨🇳 · autor de correspondenciaChina-Japan Friendship Hospital
- Guowei Song
Resumen
El texto original del estudio, en el idioma en que se publicó.
We assessed the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and community-acquired pneumonia (CAP) among Chinese children.This observational study examined children aged 3 days to 14 years (n = 1582) from the Capital Institute of Pediatrics in 2009 to 2011. There were 797 children in the CAP group and 785 controls. The CAP group was divided into 2 groups: a pneumonia group and pneumonia-induced sepsis group. The serum 25(OH)D level was estimated using micro whole blood chemiluminescence.The average serum 25(OH)D level in all samples was 25.32 ± 14.07 ng/mL, with the CAP group showing a lower value than the control group (P < .001). There were also significant differences between the pneumonia group and pneumonia-induced sepsis group (P < .001). In the pneumonia-induced sepsis group, significant differences in serum 25(OH)D levels were observed in children who received mechanical ventilation or presenting with multiple organ dysfunction (P < .01).All serum 25(OH)D levels in the pneumonia group and pneumonia-induced sepsis group were below normal levels, particularly in the sepsis group. A lower serum 25(OH)D level was associated with more serious symptoms in CAP children. Children with low serum 25(OH)D levels may be at higher risk of receiving mechanical ventilation and presenting with multiple organ dysfunction. These findings suggest that vitamin D supplements are beneficial for the treatment and prevention of CAP.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-ND).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.