Financiado en parte por H. Lundbeck A/S, Lundbeck, Lundbeck (Valby, Denmark)
Combining drug and music therapy in patients with moderate Alzheimer's disease: a randomized study
Giovagnoli AR, Manfredi V, Schifano L, Paterlini C, Parente A, Tagliavini F
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 44 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- Ministero della Salute
- Empresa
- H. Lundbeck A/S
- Empresa
- Lundbeck
- Empresa
- Lundbeck (Valby, Denmark)
- Gobierno
- Italian Ministry of Health
Según 5 financiadores declarados.
Publicación
- Publicado
- 2018-03-17 · Neurol Sci · vol. 39 · número 6 · págs. 1021–1028
- Editorial
- Springer Science+Business Media
- Citado
- 67 citas · más que el 96% de estudios similares · 6.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- De pago
- Áreas de investigación
- Music Therapy and Health · Dementia and Cognitive Impairment Research · Alzheimer's disease research and treatments
- Palabras clave
- Alzheimer's disease, active music therapy, memantine, acetylcholinesterase inhibitors, language impairment, communication, neuropsychiatric symptoms, depression, appetite, social functioning, activities of daily living
- MeSH
- humans, alzheimer disease, cholinesterase inhibitors, treatment outcome, combined modality therapy, music therapy, activities of daily living, severity of illness index, single-blind method, depression, language, appetite, neuropsychological tests, aged, female, male
6 autores
- Anna Rıta Gıovagnolı🇮🇹 · autor de correspondenciaFondazione IRCCS Istituto Neurologico Carlo Besta
- Valentina Manfredi🇮🇹Fondazione IRCCS Istituto Neurologico Carlo Besta
- Letizia Schifano🇮🇹Fondazione IRCCS Istituto Neurologico Carlo Besta
- Chiara Paterlini🇮🇹Fondazione IRCCS Istituto Neurologico Carlo Besta
- Annalisa Parente🇮🇹Fondazione IRCCS Istituto Neurologico Carlo Besta
- Fabrizio Tagliavini🇮🇹Fondazione IRCCS Istituto Neurologico Carlo Besta
Resumen
El texto original del estudio, en el idioma en que se publicó.
Alzheimer's disease (AD) can impair language, but active music therapy (AMT) and memantine (M) can improve communication. This study aimed to clarify whether adding AMT to M may improve language in comparison with drugs alone in patients with moderate AD on stable therapy with acetylcholinesterase inhibitors (AchEI). Forty-five AD patients treated with stable dose of AchEI were randomized to receive AMT plus M 20 mg/day or M 20 mg/day for 24 weeks. The Severe Impairment Battery-Language (SIB-l), SIB, Mini Mental State Examination, Neuropsychiatric Inventory (NPI), Lubben Social Network Scale, Activities of Daily Living, and Instrumental Activities of Daily Living scores at baseline and 12 and 24 weeks assessed language (primary variable) and overall cognitive, psycho-behavior, social, and functional aspects (secondary variables). The SIB-l showed a stabilization of the baseline condition in both groups, in the absence of between-group differences. The NPI depression and appetite scores significantly improved in the M-AMT group. Moreover, significantly less patients in the M-AMT group than those in the M group showed worsening of the NPI total score. Daily activities, social relationships, and overall cognitive performance did not deteriorate. In patients with moderate AD, AMT added to pharmacotherapy has no further benefits for language in comparison with pharmacotherapy alone. However, this integrated treatment can improve the psycho-behavioral profile.
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