The Effect of Vitamin D Supplementation on Glycemic Control in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis
Li X, Liu Y, Zheng Y, Wang P, Zhang Y
Nutrients · 170 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (81573429); National Natural Science Foundation of China (2017YFD0400602)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2018-03-19 · Nutrients · vol. 10 · número 3 · pág. 375
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 265 citas · más que el 98% de estudios similares · 4.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Diabetes Treatment and Management · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- vitamin D supplementation, type 2 diabetes, glycemic control, insulin resistance, HOMA-IR, serum 25-hydroxyvitamin D, fasting blood glucose, HbA1c, fasting insulin, vitamin D deficiency, dose and duration effects, obesity, Middle Eastern populations
- MeSH
- humans, diabetes mellitus, type 2, insulin resistance, vitamin d deficiency, blood glucose, vitamin d, treatment outcome, dietary supplements, adult, aged, middle aged, female, male, biomarkers, glycated hemoglobin
5 autores
- Xinyi Li🇨🇳Peking University
- Yan Liu🇨🇳Peking University
- Yingdong Zheng🇨🇳Peking University
- Peiyu Wang🇨🇳Peking University
- Yumei Zhang🇨🇳 · autor de correspondenciaPeking University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Observational studies have indicated an inverse association between vitamin D levels and the risk of diabetes, yet evidence from population interventions remains inconsistent. PubMed, EMBASE, Cochrane Library and ClinicalTrials.gov were searched up to September 2017. Data from studies regarding serum 25(OH)D, fasting blood glucose (FBG), hemoglobin A1c (HbA1c), fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR) were pooled. Twenty studies (n = 2703) were included in the meta-analysis. Vitamin D supplementation resulted in a significant improvement in serum 25(OH)D levels (weighted mean difference (WMD) = 33.98; 95%CI: 24.60-43.37) and HOMA-IR (standardized mean difference (SMD) = -0.57; 95%CI: -1.09~-0.04), but not in other outcomes. However, preferred changes were observed in subgroups as follows: short-term (WMDFBG = -8.44; 95%CI: -12.72~-4.15), high dose (WMDFBG = -8.70; 95%CI: -12.96~-4.44), non-obese (SMDFasting insulin = -1.80; 95%CI: -2.66~-0.95), Middle Easterners (WMDFBG = -10.43; 95%CI: -14.80~-6.06), baseline vitamin D deficient individuals (WMDFBG = -5.77; 95%CI: -10.48~-1.05) and well-controlled HbA1c individuals (WMDFBG = -4.09; 95%CI: -15.44~7.27). Vitamin D supplementation was shown to increase serum 25(OH)D and reduce insulin resistance effectively. This effect was especially prominent when vitamin D was given in large doses and for a short period of time, and to patients who were non-obese, Middle Eastern, vitamin D deficient, or with optimal glycemic control at baseline.
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