Changing to a vegetarian diet reduces the body creatine pool in omnivorous women, but appears not to affect carnitine and carnosine homeostasis: a randomised trial
Blancquaert L, Baguet A, Bex T, Volkaert A, Everaert I, Delanghe J, Petrovic M, Vervaet C, De Henauw S, Constantin-Teodosiu D, Greenhaff P, Derave W
The British journal of nutrition · 47 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fonds Wetenschappelijk Onderzoek
- Gobierno
- Vlaamse regering
- Subvenciones
- Fonds Wetenschappelijk Onderzoek (G.0243.11); Fonds Wetenschappelijk Onderzoek (FWO G.0243.11); Fonds Wetenschappelijk Onderzoek (G.0352.13N)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2018-03-23 · Br J Nutr · vol. 119 · número 7 · págs. 759–770
- Editorial
- Cambridge University Press
- Citado
- 69 citas · más que el 94% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Biochemical effects in animals · Muscle metabolism and nutrition · Diet and metabolism studies
- Palabras clave
- Creatine, Carnosine, Carnitine, Internal medicine, Endocrinology, Creatine Monohydrate, Medicine, Placebo
- MeSH
- humans, creatine, carnitine, carnosine, diet, vegetarian, homeostasis, adolescent, adult, female, young adult
12 autores
- Laura Blancquaert🇧🇪Ghent University Hospital; Ghent University
- Audrey Baguet🇧🇪Ghent University Hospital; Ghent University
- Tine Bex🇧🇪Ghent University Hospital; Ghent University
- Anneke Volkaert🇧🇪Ghent University Hospital; Ghent University
- Inge Everaert🇧🇪Ghent University Hospital; Ghent University
- Joris Delanghe🇧🇪Ghent University Hospital
- Mirko Petrović🇧🇪HOGENT University of Applied Sciences and Arts; Ghent University Hospital; Ghent University
- Chris Vervaet🇧🇪Ghent University
- Stefaan De Henauw🇧🇪HOGENT University of Applied Sciences and Arts; Ghent University Hospital; Ghent University
- Dumitru Constantin‐Teodosiu🇬🇧University of Nottingham; Arthritis UK; Queen's Medical Centre; Medical Research Council
- Paul Leonard Greenhaff🇬🇧University of Nottingham; Arthritis UK; Queen's Medical Centre; Medical Research Council
- Wim Derave🇧🇪 · autor de correspondenciaGhent University Hospital; Ghent University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Balanced vegetarian diets are popular, although they are nearly absent in creatine and carnosine and contain considerably less carnitine than non-vegetarian diets. Few longitudinal intervention studies investigating the effect of a vegetarian diet on the availability of these compounds currently exist. We aimed to investigate the effect of transiently switching omnivores onto a vegetarian diet for 6 months on muscle and plasma creatine, carnitine and carnosine homeostasis. In a 6-month intervention, forty omnivorous women were ascribed to three groups: continued omnivorous diet (control, n 10), vegetarian diet without supplementation (Veg+Pla, n 15) and vegetarian diet combined with daily β-alanine (0·8-0·4 g/d) and creatine supplementation (1 g creatine monohydrate/d) (Veg+Suppl, n 15). Before (0 months; 0M), after 3 months (3M) and 6 months (6M), a fasted venous blood sample and 24-h urine was collected, and muscle carnosine content was determined by proton magnetic resonance spectroscopy (1H-MRS). Muscle biopsies were obtained at 0M and 3M. Plasma creatine and muscle total creatine content declined from 0M to 3M in Veg+Pla (P=0·013 and P=0·009, respectively), whereas plasma creatine increased from 0M in Veg+Suppl (P=0·004). None of the carnitine-related compounds in plasma or muscle showed a significant time×group interaction effect. 1H-MRS-determined muscle carnosine content was unchanged over 6M in control and Veg+Pla, but increased in Veg+Suppl in soleus (P<0·001) and gastrocnemius (P=0·001) muscle. To conclude, the body creatine pool declined over a 3-month vegetarian diet in omnivorous women, which was ameliorated when accompanied by low-dose dietary creatine supplementation. Carnitine and carnosine homeostasis was unaffected by a 3- or 6-month vegetarian diet, respectively.
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