Time-restricted feeding influences immune responses without compromising muscle performance in older men
Gasmi M, Sellami M, Denham J, Padulo J, Kuvacic G, Selmi W, Khalifa R
Nutrition (Burbank, Los Angeles County, Calif.) · 49 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2018-02-02 · Nutrition · vol. 51-52 · págs. 29–37
- Editorial
- Elsevier BV
- Citado
- 69 citas · más que el 94% de estudios similares · 3.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 78 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Exercise and Physiological Responses · Muscle metabolism and nutrition
- Palabras clave
- time-restricted feeding, immune response, muscle performance, older men, natural killer cells, hematocrit, neutrophils, lymphocytes, immunosenescence, low-grade inflammation, exercise capacity, aging
- MeSH
- leukocytes, neutrophils, killer cells, natural, humans, hematocrit, fasting, age factors, adult, middle aged, male, muscle strength, immunity, innate, young adult
7 autores
- Maha Gasmi
- Maha Sellami🇹🇳🇭🇷 · autor de correspondenciaCentre National de la Médecine et des Sciences des Sports; University of Split
- Joshua Denham🇦🇺University of New England
- Johnny Padulo🇮🇹🇹🇳🇭🇷Università degli Studi eCampus; Centre National de la Médecine et des Sciences des Sports; University of Split
- Goran Kuvačić🇭🇷University of Split
- Walid Selmi
- Riadh Khalıfa
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
This study examined the effect of 12 wk of time-restricted feeding (TRF) on complete blood cell counts, natural killer cells, and muscle performance in 20- and 50-year-old men.
Methods
Forty active and healthy participants were randomly divided into young experimental, young control, aged experimental, and aged control group. Experimental groups participated in TRF. Before (P1) and after (P2) TRF, participants performed a maximal exercise test to quantify muscle power. Resting venous blood samples were collected for blood count calculation.
Results
No changes were identified in muscle power in all groups after TRF (P > 0.05). At P1, red cells, hemoglobin, and hematocrit were significantly higher in young participants compared with elderly participants (P 0.05). At P1, white blood cells and neutrophils were significantly higher in young participants compared with elderly participants (P 0.05) difference among them. Lymphocytes decreased significantly in the aged experimental group at P2 (P + and NKCD56+ decreased significantly in experimental groups at P2 (P +, and CD8+ levels (P > 0.05).
Conclusion
TRF decreases hematocrit, total white blood cells, lymphocytes, and neutrophils in young and older men. TRF may be effective in preventing inflammation by decreasing natural killer cells. As such, TRF could be a lifestyle strategy to reduce systemic low-grade inflammation and age-related chronic diseases linked to immunosenescence, without compromising physical performance.
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