25-Hydroxyvitamin D Serum Levels and Endometriosis: Results of a Case-Control Study
Buggio L, Somigliana E, Pizzi MN, Dridi D, Roncella E, Vercellini P
Reproductive sciences (Thousand Oaks, Calif.) · 21 citas
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Cómo se estudió
- Diseño
- Estudio de casos y controles (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2018-03-27 · Reprod Sci · vol. 26 · número 2 · págs. 172–177
- Editorial
- Springer Nature
- Citado
- 39 citas · más que el 92% de estudios similares · 3.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Endometriosis Research and Treatment · Vitamin D Research Studies · Uterine Myomas and Treatments
- Palabras clave
- Endometriosis, Medicine, Vitamin D and neurology, Internal medicine, Case-control study, Pathogenesis, vitamin D deficiency, Gastroenterology, Gynecology
- MeSH
- humans, ovarian diseases, endometriosis, vitamin d deficiency, vitamin d, case-control studies, adolescent, adult, middle aged, female, young adult
6 autores
- Laura Buggio🇮🇹 · autor de correspondenciaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Edgardo Somigliana🇮🇹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Mara Nicoletta Pizzi🇮🇹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Dhouha Dridi🇮🇹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Elena Roncella🇮🇹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Paolo Vercellini🇮🇹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Resumen
El texto original del estudio, en el idioma en que se publicó.
The immunomodulatory, anti-inflammatory, and antiproliferative properties of vitamin D have laid the basis for a possible function of this prohormone in the pathogenesis of endometriosis. The aim of this case-control study was to investigate vitamin D status, by measuring 25-hydroxyvitamin D [25(OH)D] serum levels, in women with and without endometriosis. Only Italian women of Caucasian origin aged between 18 and 45 years were deemed eligible. Enrollment was limited to the period October to May. Cases and controls were matched for month of recruitment and secondarily for age and parity. Overall, 434 women were enrolled (endometriosis n = 217; controls n = 217). The group of cases included 127 women with ovarian endometrioma and 90 patients with deep endometriosis. Mean (standard deviation) levels of 25(OH)D in women with and without endometriosis were 17.9 (7.0) ng/mL and 18.4 (7.6) ng/mL, respectively ( P = .46). Analyzing the two endometriosis subgroups separately, no statistically significant differences emerged (18.7 [7.4] ng/mL in deep endometriosis group vs 17.3 [6.6] ng/mL in women with ovarian endometrioma; P = .14). Comparing the subgroup of women with deep endometriosis with paired controls, no differences occurred (18.7 [7.4] ng/mL vs 18.5 [7.7] ng/mL, P = .80). Similar data emerged when performing the same analysis for ovarian endometriomas (17.4 [6.6] ng/mL vs 18.3 [7.6] ng/mL, P = .23). The results of the present case-control study do not support an association between serum vitamin D levels and different phenotypes of endometriosis.
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