The Role of Cruciferous Vegetables and Isothiocyanates for Lung Cancer Prevention: Current Status, Challenges, and Future Research Directions
Zhang Z, Bergan R, Shannon J, Slatore CG, Bobe G, Takata Y
Molecular nutrition & food research · 24 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Veterans Affairs
- Universidad u hospital
- Knight Cancer Institute OHSU/OSU Cancer Prevention and Control Initiative
Según 2 financiadores declarados.
Publicación
- Publicado
- 2018-04-17 · Mol Nutr Food Res · vol. 62 · número 18 · pág. e1700936
- Editorial
- Wiley
- Citado
- 29 citas · más que el 74% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 104 trabajos
- Acceso
- De pago
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Glutathione Transferases and Polymorphisms · Nitrogen and Sulfur Effects on Brassica
- Palabras clave
- Cruciferous vegetables, Lung cancer, Medicine, Cancer, Odds ratio, Confidence interval, Environmental health, Internal medicine, Sulforaphane, Oncology, Cancer research
- MeSH
- humans, brassicaceae, vegetables, lung neoplasms, isothiocyanates, anticarcinogenic agents, diet, risk factors, clinical trials as topic, biomarkers, observational studies as topic
6 autores
- Zhenzhen Zhang🇺🇸Oregon Health & Science University
- Raymond C. Bergan🇺🇸Oregon Health & Science University
- Jackilen Shannon🇺🇸Oregon Health & Science University
- Christopher G. Slatore🇺🇸Oregon Health & Science University; VA Portland Health Care System
- Gerd Bobe🇺🇸Oregon State University
- Yumie Takata🇺🇸 · autor de correspondenciaOregon State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Lung cancer remains a leading cause of cancer-related deaths in the United States. Although smoking and air pollution exposure are primary risk factors of lung cancer, diet has also been reported to contribute to lung cancer risk. Cruciferous vegetables contain many bioactive compounds that alter the detoxification process of air-borne carcinogenic compounds and, thereby, may decrease lung cancer risk. In the meta-analysis of 31 observational studies, cruciferous vegetable intake is inversely associated with lung cancer risk (summary odds ratio/relative risk = 0.81 and 95% confidence interval = 0.74-0.89 for comparing the highest with lowest intake categories). More observational studies need to measure urinary isothiocyanate (ITC) concentrations and investigate their association with lung cancer risk in populations with relatively high intake of cruciferous vegetables. Current evidence is limited to two phase 2 clinical trials with incomplete reporting. Hence, more short-term clinical phase 2 trials need to examine effects of various amounts and types of cruciferous vegetables on biomarkers of risk and efficacy before a large phase 3 trial can be conducted to assess effects upon lung cancer risk. This would help further elucidate whether the inverse association observed with self-reported cruciferous vegetable intake is indeed due to ITC content or other bioactive compounds.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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