Financiado en parte por DSM Nutritional Products Ltd., R&D Human Nutrition and Health
The association between 25-hydroxyvitamin D concentration, physical performance and frailty status in older adults
Vaes AMM, Brouwer-Brolsma EM, Toussaint N, de Regt M, Tieland M, van Loon LJC, de Groot LCPGM
European journal of nutrition · 37 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- Top Institute Food and Nutrition
- Empresa
- DSM Nutritional Products Ltd., R&D Human Nutrition and Health
Según 2 financiadores declarados.
Publicación
- Publicado
- 2018-04-24 · Eur J Nutr · vol. 58 · número 3 · págs. 1173–1181
- Editorial
- Springer Science+Business Media
- Citado
- 64 citas · más que el 96% de estudios similares · 5.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health in Aging · GDF15 and Related Biomarkers
- Palabras clave
- Vitamin D and neurology, Medicine, Grip strength, vitamin D deficiency, Population, Cross-sectional study, Internal medicine, Timed Up and Go test, Physical therapy, Environmental health, Pathology
- MeSH
- humans, vitamin d, hand strength, geriatric assessment, cross-sectional studies, aged, frail elderly, netherlands, female, male, frailty, physical functional performance
7 autores
- Anouk M.M. Vaes🇳🇱 · autor de correspondenciaTiFN; Wageningen University & Research
- Elske Maria Brouwer-Brolsma🇳🇱Wageningen University & Research
- Nicole Toussaint🇳🇱Wageningen University & Research
- Margot de Regt🇳🇱Wageningen University & Research
- Michael Tieland🇳🇱TiFN; Wageningen University & Research
- Luc J. C. van Loon🇳🇱Maastricht University Medical Centre; Maastricht University; TiFN
- C.P.G.M. de Groot🇳🇱TiFN; Wageningen University & Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Sufficient 25-hydroxyvitamin D (25(OH)D) concentrations might prevent a decline in physical performance, and are considered important for the prevention of frailty. This study investigates the association of serum 25(OH)D concentration with physical performance and frailty status in Dutch older adults.
Methods
This cross-sectional study included 756 men and women, aged ≥ 65 years. Serum 25(OH)D concentration and frailty status (Fried criteria) were assessed in the total population. Screening for frailty status included functional tests of gait speed and hand grip strength. In a subgroup (n = 494), the Timed Up and Go test (TUG) and knee-extension strength were measured. Associations of serum 25(OH)D status with physical performance were examined by multiple linear regression. Prevalence ratios (PR) were used to quantify associations between serum 25(OH)D deficiency (< 50 nmol/L) and frailty.
Results
In total, 45% of the participants were vitamin D deficient. Participants with vitamin D status 75 nmol/L. No significant associations with serum 25(OH)D concentrations were observed for handgrip strength or knee-extension strength. Participants with serum 25(OH)D status < 50 nmol/L were about two times more likely to be frail compared to participants with serum 25(OH)D status ≥ 50 nmol/L. No significant associations were observed between the pre-frail state and serum 25(OH)D status.
Conclusion
In this study, serum 25(OH)D concentrations were significantly associated with frailty status and measures of physical performance, including gait speed and TUG, but not with strength-related outcomes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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