Effects of Astaxanthin and Docosahexaenoic-Acid-Acylated Astaxanthin on Alzheimer's Disease in APP/PS1 Double-Transgenic Mice
Che H, Li Q, Zhang T, Zhang T, Wang D, Yang L, Xu J, Yanagita T, Xue C, Chang Y, Wang Y
Journal of agricultural and food chemistry · 92 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Ministry of Education of the People's Republic of China
- Gobierno
- Japan Society for the Promotion of Science
- Gobierno
- Government of Shandong Province
- Gobierno
- Shandong Province
- Gobierno
- Ministry of Education of the People's Republic of China
- Subvenciones
- National Natural Science Foundation of China (U1606403); Ministry of Education of the People's Republic of China (201762028); National Natural Science Foundation of China (31330060); Japan Society for the Promotion of Science (16K00890); Government of Shandong Province (U1606403)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2018-04-25 · J Agric Food Chem · vol. 66 · número 19 · págs. 4948–4957
- Editorial
- American Chemical Society
- Citado
- 150 citas · más que el 97% de estudios similares · 4.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 30 trabajos
- Acceso
- De pago
- Áreas de investigación
- Antioxidant Activity and Oxidative Stress · Coenzyme Q10 studies and effects · Fatty Acid Research and Health
- Palabras clave
- Neuroinflammation, Docosahexaenoic acid, Astaxanthin, Morris water navigation task, Oxidative stress, Senile plaques, Pharmacology, Genetically modified mouse, Chemistry, Pathogenesis, Alzheimer's disease, Medicine, Transgene, Biochemistry, Endocrinology, Internal medicine, Fatty acid, Polyunsaturated fatty acid, Hippocampus, Disease
- MeSH
- animals, mice, transgenic, humans, mice, alzheimer disease, xanthophylls, docosahexaenoic acids, amyloid beta-protein precursor, learning, memory, acylation, female, male, presenilin-1
10 autores
- Hongxia Che🇨🇳Ocean University of China
- Qian Li🇨🇳Ocean University of China
- Tiantian Zhang🇨🇳Ocean University of China
- Dandan Wang🇨🇳Ocean University of China
- Lu Yang🇨🇳Ocean University of China
- Jie Xu🇨🇳Ocean University of China
- Teruyoshi Yanagita🇯🇵Saga University
- Changhu Xue🇨🇳Qingdao National Laboratory for Marine Science and Technology; Ocean University of China
- Yaoguang Chang🇨🇳 · autor de correspondenciaOcean University of China
- Yuming Wang🇨🇳 · autor de correspondenciaQingdao National Laboratory for Marine Science and Technology; Ocean University of China
Resumen
El texto original del estudio, en el idioma en que se publicó.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with the characteristics of senile plaques, neuroinflammation, neurofibrillary tangles, and destruction of synapse structure stability. Previous studies have verified the protective effects of astaxanthin (AST). However, whether synthesized docosahexaenoic-acid-acylated AST diesters (AST-DHA) could delay AD pathogenesis remains unclear. In the present study, APP/PSEN1 (APP/PS1) double-transgenic mice were administrated with AST and AST-DHA for 2 months. The results of radial 8-arm maze and Morris water maze tests showed that AST-DHA exerted more significant effects than AST in enhancing learning and memory levels of APP/PS1 mice. Further mechanical studies suggested that AST-DHA was superior to AST in regulating the parameters of oxidative stress, reducing tau hyperphosphorylation, suppressing neuroinflammation, and regulating inflammasome expression and activation in APP/PS1 mice. The findings suggested that AST-DHA attenuated cognitive disorders by reducing pathological features in APP/PS1 mice, suggesting that AST-DHA might be a potential therapeutic agent for AD.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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