Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials
Avgerinos KI, Spyrou N, Bougioukas KI, Kapogiannis D
Experimental gerontology · 104 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- Intramural NIH HHS
- Subvenciones
- National Institutes of Health (Z99 AG999999); National Institute on Aging (ZIAAG000975)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2018-04-25 · Exp Gerontol · vol. 108 · págs. 166–173
- Editorial
- Elsevier BV
- Citado
- 163 citas · más que el 63% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 56 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Muscle metabolism and nutrition · Biochemical effects in animals · Neurological Disorders and Treatments
- Palabras clave
- creatine supplementation, cognitive function, short-term memory, intelligence, executive function, attention, response inhibition, verbal fluency, reaction time, mental fatigue, vegetarians, meat-eaters, healthy individuals, aging, neuroprotection
- MeSH
- humans, creatine, intelligence, cognition, memory, short-term, dietary supplements, randomized controlled trials as topic, healthy volunteers
4 autores
- Konstantinos Ioannis Avgerinos🇬🇷 · autor de correspondenciaAristotle University of Thessaloniki; Hellenic Air Force; Hellenic Airforce General Hospital
- Nikolaos Spyrou🇬🇷National and Kapodistrian University of Athens; Hellenic Air Force; Hellenic Airforce General Hospital
- Konstantinos I. Bougioukas🇬🇷Aristotle University of Thessaloniki
- Dimitrios Kapogiannis🇺🇸National Institute on Aging
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
Creatine is a supplement used by sportsmen to increase athletic performance by improving energy supply to muscle tissues. It is also an essential brain compound and some hypothesize that it aids cognition by improving energy supply and neuroprotection. The aim of this systematic review is to investigate the effects of oral creatine administration on cognitive function in healthy individuals.
Methods
A search of multiple electronic databases was performed for the identification of randomized clinical trials (RCTs) examining the cognitive effects of oral creatine supplementation in healthy individuals.
Results
Six studies (281 individuals) met our inclusion criteria. Generally, there was evidence that short term memory and intelligence/reasoning may be improved by creatine administration. Regarding other cognitive domains, such as long-term memory, spatial memory, memory scanning, attention, executive function, response inhibition, word fluency, reaction time and mental fatigue, the results were conflicting. Performance on cognitive tasks stayed unchanged in young individuals. Vegetarians responded better than meat-eaters in memory tasks but for other cognitive domains no differences were observed.
Conclusions
Oral creatine administration may improve short-term memory and intelligence/reasoning of healthy individuals but its effect on other cognitive domains remains unclear. Findings suggest potential benefit for aging and stressed individuals. Since creatine is safe, future studies should include larger sample sizes. It is imperative that creatine should be tested on patients with dementias or cognitive impairment.
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