Effect of dietary nitrate supplementation on conduit artery blood flow, muscle oxygenation, and metabolic rate during handgrip exercise
Craig JC, Broxterman RM, Smith JR, Allen JD, Barstow TJ
Journal of applied physiology (Bethesda, Md. : 1985) · 30 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Aeronautics and Space Administration
- Universidad u hospital
- College of Veterinary Medicine, Kansas State University
- Gobierno
- National Aeronautics and Space Administration (NASA)
- Subvenciones
- National Aeronautics and Space Administration (NNX11AM05A); National Aeronautics and Space Administration (NNX10AK60G)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2018-05-03 · J Appl Physiol (1985) · vol. 125 · número 2 · págs. 254–262
- Editorial
- American Physiological Society
- Citado
- 35 citas · más que el 94% de estudios similares · 4.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Cardiovascular and exercise physiology · Heart Rate Variability and Autonomic Control · Nitric Oxide and Endothelin Effects
- Palabras clave
- Crossover study, Internal medicine, Nitrate, Heart rate, Dietary Nitrate, Placebo, Blood pressure, Myoglobin, Endocrinology, Hemoglobin, Oxygenation, Medicine, Exercise physiology, Cardiology, Chemistry, Nitrite, Biochemistry
- MeSH
- muscle, skeletal, brachial artery, animals, humans, rats, nitrates, hemoglobins, myoglobin, exercise test, hand strength, cross-over studies, double-blind method, oxygen consumption, blood pressure, regional blood flow, exercise tolerance, muscle contraction, dietary supplements, adult, female, male
5 autores
- Jesse C. Craig🇺🇸 · autor de correspondenciaKansas State University
- Ryan Michael Broxterman🇺🇸Kansas State University
- Joshua R. Smith🇺🇸Kansas State University
- Jason David Allen🇺🇸Duke Medical Center; University of Virginia
- Thomas Jackson Barstow🇺🇸Kansas State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary nitrate supplementation has positive effects on mitochondrial and muscle contractile efficiency during large muscle mass exercise in humans and on skeletal muscle blood flow (Q̇) in rats. However, concurrent measurement of these effects has not been performed in humans. Therefore, we assessed the influence of nitrate supplementation on Q̇ and muscle oxygenation characteristics during moderate- (40 %peak) and severe-intensity(85% peak) handgrip exercise in a randomized, double-blind, crossover design. Nine healthy men (age: 25 ± 2 yr) completed four constant-power exercise tests (2/intensity) randomly assigned to condition [nitrate-rich (nitrate) or nitrate-poor (placebo) beetroot supplementation] and intensity (40 or 85% peak). Resting mean arterial pressure was lower after nitrate compared with placebo (84 ± 4 vs. 89 ± 4 mmHg, P 0.05) but was elevated throughout 85% peak ( P 2) was not different at the end of exercise; however, the V̇o2 primary amplitude at the onset of exercise was elevated after nitrate for the 85% peak work rate (96 ± 20 vs. 72 ± 12 ml/min, P 2 kinetics in young adults but does not augment Q̇ or reduce steady-state V̇o2 during small muscle mass handgrip exercise. NEW & NOTEWORTHY We show that acute dietary nitrate supplementation via beetroot juice increases the amplitude and speed of local muscle V̇o2 on kinetics parameters during severe- but not moderate-intensity handgrip exercise. These changes were found in the absence of an increased blood flow response, suggesting that the increased V̇o2 was attained via improvements in fractional O2 extraction and/or spatial distribution of blood flow within the exercising muscle.
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