Effects of p-Synephrine and Caffeine Ingestion on Substrate Oxidation during Exercise
Gutiérrez-Hellín J, Del Coso J
Medicine and science in sports and exercise · 27 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2018-05-04 · Med Sci Sports Exerc · vol. 50 · número 9 · págs. 1899–1906
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 35 citas · más que el 86% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Pharmacology and Obesity Treatment · Adipose Tissue and Metabolism
- Palabras clave
- p-synephrine, caffeine, fat oxidation, substrate oxidation, physical activity, thermogenic supplements, energy expenditure, heart rate, combination supplementation, weight loss products
- MeSH
- adipose tissue, humans, synephrine, caffeine, exercise, double-blind method, energy metabolism, oxidation-reduction, oxygen consumption, heart rate, dietary supplements, adolescent, adult, female, male, young adult
2 autores
- Jorge Gutiérrez‐Hellín🇪🇸Camilo José Cela University
- Juan Del Coso🇪🇸Camilo José Cela University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Caffeine and p-synephrine are substances usually included in commercially available products for weight loss because of their purported thermogenic effects. However, scientific information is lacking about the effects of combining these substances on substrate oxidation during exercise. The purpose of this investigation was to determine the isolated and combined effects of p-synephrine and caffeine on fat oxidation rate during exercise.
Methods
In a double-blind randomized experiment, 13 healthy subjects participated in four experimental trials after the ingestion of a capsule containing a placebo, 3 mg·kg of caffeine, 3 mg·kg of p-synephrine, or the combination of these doses of caffeine and p-synephrine. Energy expenditure and substrate oxidation rates were measured by indirect calorimetry during a cycle ergometer ramp test from 30% to 90% of V˙O2max.
Results
In comparison with the placebo, the ingestion of caffeine, p-synephrine, or p-synephrine + caffeine did not alter total energy expenditure or heart rate during the whole exercise test. However, the ingestion of caffeine (0.44 ± 0.15 g·min, P = 0.03), p-synephrine (0.43 ± 0.19 g·min, P < 0.01), and p-synephrine + caffeine (0.45 ± 0.15 g·min, P = 0.02) increased the maximal rate of fat oxidation during exercise when compared with the placebo (0.30 ± 0.12 g·min). The exercise intensity that elicited maximal fat oxidation was similar in all trials (~46.2% ± 10.2% of V˙O2max).
Conclusion
Caffeine, p-synephrine, and p-synephrine + caffeine increased the maximal rate of fat oxidation during exercise compared with a placebo, without modifying energy expenditure or heart rate. However, the coingestion of p-synephrine and caffeine did not present an additive effect to further increase fat oxidation during exercise.
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