Maternal dietary nitrate intake and risk of neural tube defects: A systematic review and dose-response meta-analysis
Kakavandi NR, Hasanvand A, Ghazi-Khansari M, Sezavar AH, Nabizadeh H, Parohan M
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 13 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Tehran University of Medical Sciences and Health Services
- Subvenciones
- Tehran University of Medical Sciences and Health Services (97-01-61-37510)
Según 1 financiador declarado.
Publicación
- Publicado
- 2018-05-12 · Food Chem Toxicol · vol. 118 · págs. 287–293
- Editorial
- Elsevier BV
- Citado
- 18 citas · más que el 35% de estudios similares · 0.2× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- De pago
- Áreas de investigación
- Folate and B Vitamins Research · Nutritional Studies and Diet · Pharmacological Effects and Toxicity Studies
- Palabras clave
- dietary nitrate, neural tube defects, maternal nutrition, teratogenicity, dose-response relationship, nonlinear dose-response relationship, congenital malformations
- MeSH
- humans, neural tube defects, nitrates, diet, risk factors, maternal exposure, dose-response relationship, drug, female
6 autores
- Nader Rahimi Kakavandi🇮🇷Tehran University of Medical Sciences
- Amin Hasanvand🇮🇷Lorestan University of Medical Sciences
- Mahmoud Ghazi‐Khansari🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
- Ahmad Habibian🇮🇷Tehran University of Medical Sciences
- Hassan Nabizadeh🇮🇷Tehran University of Medical Sciences
- Mohammad Parohan🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Despite growing evidence for the potential teratogenicity of nitrate, knowledge about the dose-response relationship of dietary nitrate intake and risk of specific birth defects such as neural tube defects (NTDs) is limited. Therefore, the aim of this meta-analysis was to synthesize the knowledge about the dose-response relation between maternal dietary nitrate intake and the risk of NTDs. We conducted a systematic search in PubMed, ISI Web of Science and Scopus up to February 2018 for observational studies. Risk ratios (RRs) and 95% confidence intervals (95% CI) were calculated using a random-effects model for highest versus lowest intake categories. The linear and non-linear relationships between nitrate intake and risk of NTDs were also investigated. Overall, 5 studies were included in the meta-analyses. No association was observed between nitrate intake and NTDs risk in high versus low intake (RR: 1.33; 95% CI: 0.89-1.99, p = 0.158) and linear dose-response (RR: 1.03; 95% CI: 0.99-1.07, p = 0.141) meta-analysis. However, there were positive relationships between nitrate intake and risk of NTDs in non-linear (pnon-linearity<0.05) model. Findings from this dose-response meta-analysis indicate that maternal nitrate intake higher than ∼3 mg/day is positively associated with NTDs risk.
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